2-Oleoylglycerol
2-Oleoylglycerol structure
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Common Name | 2-Oleoylglycerol | ||
|---|---|---|---|---|
| CAS Number | 3443-84-3 | Molecular Weight | 356.54000 | |
| Density | 0.969 g/cm3 | Boiling Point | 485.4ºC at 760mmHg | |
| Molecular Formula | C21H40O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 113ºC | |
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Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol.
J. Physiol. 593(8) , 2097-109, (2015) Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensing to food intake and the activation of brain circuits remai... |
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TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.
Am. J. Physiol. Lung Cell. Mol. Physiol. 307(2) , L158-72, (2014) The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel expr... |
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Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor.
Bioorg. Med. Chem. 23 , 5922-31, (2015) MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-5-sulfona... |
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A novel method for the synthesis of symmetrical triacylglycerols by enzymatic transesterification.
Bioresour. Technol. 196 , 559-65, (2015) A novel two-step enzymatic method is described in this study to synthesize symmetrical triacylglycerols (TAGs) with arachidonic acid (ARA) at the sn-2 position. The processes included the synthesis of 2-monoacylglycerols (2-MAGs) rich in 2-arachidonoylglycero... |
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Effect of compounds affecting ABCA1 expression and CETP activity on the HDL pathway involved in intestinal absorption of lutein and zeaxanthin.
Lipids 49(12) , 1233-43, (2014) The antioxidant xanthophylls lutein and zeaxanthin are absorbed from the diet in a process involving lipoprotein formation. Selective mechanisms exist for their intestinal uptake and tissue-selective distribution, but these are poorly understood. We investiga... |
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Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis.
J. Biol. Chem. 291 , 2602-15, (2016) Dietary triglycerides (TG) are absorbed by the enterocytes of the small intestine after luminal hydrolysis into monacylglycerol and fatty acids. Before secretion on chylomicrons, these lipids are reesterified into TG, primarily through the monoacylglycerol pa... |
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CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay.
ChemBioChem. 9 , 2704-2710, (2008) Monoglyceride lipase (MGL) plays a major role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). This endocannabinoid is known to mediate a large number of physiological processes, and its regulation is thought to be of great therapeuti... |
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Potential use of avocado oil on structured lipids MLM-type production catalysed by commercial immobilised lipases.
PLoS ONE 9(9) , e107749, (2014) Structured Lipids are generally constituents of functional foods. Growing demands for SL are based on a fuller understanding of nutritional requirements, lipid metabolism, and improved methods to produce them. Specifically, this work was aimed to add value to... |
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Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides.
PLoS ONE 8 , e67865, (2013) Lipid metabolism is critical to coordinate organ development and physiology in response to tissue-autonomous signals and environmental cues. Changes to the availability and signaling of lipid mediators can limit competitiveness, adaptation to environmental st... |
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2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
J. Clin. Endocrinol. Metab. 96 , E1409-1417, (2011) Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (G... |