3443-84-3

3443-84-3 structure

Name: 2-Oleoylglycerol
Chemical Name: 2-oleoylglycerol
CAS Number: 3443-84-3
Molecular Formula: C₂₁H₄₀O₄
Molecular Weight: 356.54000
Catalog: Signaling Pathways GPCR/G Protein GPR119
Create Date: 2018-09-21 20:45:52
Modify Date: 2024-01-04 22:25:00
2-Oleoylglycerol is a dietary naturally occurring lipid. 2-Oleoylglycerol is a GPR119 agonist, with an EC50 of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo[1][2].

Name	2-oleoylglycerol
Synonyms	glycerine monooleate 2-o-Kresyloxy-glutarsaeure-diethylester 2-MONOOLEIN 1,3-dihydroxypropan-2-yl oleate 2-monooleoylglycerol 2-Oleoylglycerol glycerin oleate

Description	2-Oleoylglycerol is a dietary naturally occurring lipid. 2-Oleoylglycerol is a GPR119 agonist, with an EC50 of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR119 Research Areas >> Metabolic Disease
Target	IC50: 2.5 μM (hGPR119) (in COS-7 cells)[1]
References	[1]. Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. [2]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84.

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