2,4,6-Triiodophenol
2,4,6-Triiodophenol structure
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Common Name | 2,4,6-Triiodophenol | ||
|---|---|---|---|---|
| CAS Number | 609-23-4 | Molecular Weight | 471.801 | |
| Density | 3.1±0.1 g/cm3 | Boiling Point | 316.3±42.0 °C at 760 mmHg | |
| Molecular Formula | C6H3I3O | Melting Point | 157-159 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 145.1±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Distribution of dehalogenation activity in subseafloor sediments of the Nankai Trough subduction zone.
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1616) , 20120249, (2013) Halogenated organic matter buried in marine subsurface sediment may serve as a source of electron acceptors for anaerobic respiration of subseafloor microbes. Detection of a diverse array of reductive dehalogenase-homologous (rdhA) genes suggests that subseaf... |
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Comparative developmental toxicity of new aromatic halogenated DBPs in a chlorinated saline sewage effluent to the marine polychaete Platynereis dumerilii.
Environ. Sci. Technol. 47(19) , 10868-76, (2013) Using seawater for toilet flushing may introduce high levels of bromide and iodide into a city's sewage treatment works, and result in the formation of brominated and iodinated disinfection byproducts (DBPs) during chlorination to disinfect sewage effluents. ... |
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Fast speciation analysis of iodophenol compounds in river waters by capillary electrophoresis-inductively coupled plasma-mass spectrometry with off-line solid-phase microextraction.
Electrophoresis 25(12) , 1843-51, (2004) An analytical methodology for the fast separation and determination of iodophenol species in natural water samples was developed using capillary electrophoresis (CE) coupled to inductively coupled plasma-mass spectrometry (ICP-MS). Based on the element-specif... |
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Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver.
Toxicol. Sci. 124(2) , 339-47, (2011) Halogenated contaminants, particularly brominated flame retardants, disrupt circulating levels of thyroid hormones (THs), potentially affecting growth and development. Disruption may be mediated by impacts on deiodinase (DI) activity, which regulate the level... |
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Characterization of plasma triiodophenol binding proteins in vertebrates and tissue distribution of triiodophenol in Rana catesbeiana tadpoles.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 153(3) , 328-35, (2011) We investigated the interaction of 2,4,6-triiodophenol (TIP), a potent thyroid hormone disrupting chemical, with serum proteins from rainbow trout (Onchorhynchus mykiss), bullfrog (Rana catesbeiana), chicken (Gallus gallus), pig (Sus scrofa domesticus), and r... |
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Inhibiting transthyretin amyloid fibril formation via protein stabilization.
Proc. Natl. Acad. Sci. U. S. A. 93(26) , 15051-6, (1996) Transthyretin (TTR) amyloid fibril formation is observed systemically in familial amyloid polyneuropathy and senile systemic amyloidosis and appears to be the causative agent in these diseases. Herein, we demonstrate conclusively that thyroxine (10.8 microM) ... |
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Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance.
Cancer Res. 68(15) , 6313-23, (2008) The poor prognosis of pancreatic cancer and poor sensitivity to current therapeutics, associated with resistance to apoptosis, urge the search for new drugs. We previously described the induction of caspase-independent mithochondrial death in leukemia cells b... |
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Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor.
Pharm. Res. 23(7) , 1533-42, (2006) The aim of this study was to explore the possibility of achieving a practical dosing regimen for 2,4,6-triiodophenol (AM-24), a new leukotriene B4 (LTB4) synthesis inhibitor. First, a model capable of dealing with the nonlinearity in its pharmacokinetic profi... |
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Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc.
Mol. Cancer Ther. 5(5) , 1166-75, (2006) 2,4,6-Triiodophenol (Bobel-24, AM-24) was originally described as a nonsteroid antiinflammatory molecule. We have synthesized three derivatives of Bobel-24 (Bobel-4, Bobel-16, and Bobel-30) and tested their activities as putative antileukemic agents. We have ... |
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Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs.
Vet. Parasitol. 155(3-4) , 308-13, (2008) The efficacy of the anti-inflammatory drug Bobel-24 against experimental infection by Cryptosporidium parvum was evaluated in neonatal lambs. The animals were treated by oral administration of the drug at 50 or 500 mg/kg of body weight. The prophylactic/thera... |