Minaprine
Minaprine structure
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Common Name | Minaprine | ||
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| CAS Number | 25905-77-5 | Molecular Weight | 298.38 | |
| Density | 1.156g/cm3 | Boiling Point | 531.2ºC at 760 mmHg | |
| Molecular Formula | C17H22N4O | Melting Point | 122° | |
| MSDS | Chinese USA | Flash Point | 275.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Multicentric double-blind study comparing efficacy and safety of minaprine and imipramine in dysthymic disorders.
Neuropsychobiology 31(2) , 68-75, (1995) This multicentre study compares the therapeutic efficacy and safety of minaprine (200 mg) to that of imipramine (50, 75, 100 mg) in the treatment of patients over 40 years suffering from dysthymic disorders as diagnosed according to DSM III. After 4-7 days on... |
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Computerised psychomotor performance testing: a comparative study of the single dose pharmacodynamics of minaprine and amitriptyline in young and elderly subjects.
Br. J. Clin. Pharmacol. 36(4) , 376-9, (1993) The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-blind crossover trial using an automated psychomotor test bat... |
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Cholinomimetic activity of minaprine is related to the amelioration of delayed neuronal death in gerbils.
Physiol. Behav. 52(1) , 141-7, (1992) We attempted to determine if the cholinomimetic activity of the psychotropic drug minaprine was related to the amelioration of the delayed neuronal death induced by cerebral ischemia in Mongolian gerbils. Minaprine improved the passive avoidance deficit induc... |
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Minaprine facilitates acquisition and retrieval of an active avoidance response in the rat.
Pharmacol. Biochem. Behav. 45(2) , 481-5, (1993) The nootropic activity of 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl-pyridazine dihydrochloride (minaprine) has been investigated in intact male, adult Long Evans rats by means of an active avoidance paradigm. In the light-dark box apparatus, the rat had t... |
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Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test.
Neurosci. Lett. 166(1) , 69-72, (1994) Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine... |
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Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine.
Neurochem. Int. 24(1) , 37-41, (1994) Involvement of protein kinase C (PKC) activation in the regulation of acetylcholine (ACh) release from rat hippocampal slices by minaprine, [3(2-morpholinoethylamino)-4-methyl-6-phenylpyridazine] was investigated. Phorbol esters such as 4 beta-phorbol 12,13-d... |
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[Randomized double-blind comparative study of minaprine (200mg/j) and of placebo on memory loss].
Therapie. 51(2) , 155-62, (1996) Thirty five subjects (age: 45-69 years) with subjective memory loss, without any other neuropsychiatric or somatic disease, were recruited in a phase II study. This double blind randomized versus placebo controlled study compared the effects of minaprine (200... |
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[Evaluation by poison control centers of minaprine from the modification of tablet dosages].
Therapie. 51(5) , 582-5, (1996) By 1990, the Clin Midy (SANOFI) laboratory had modified the dose of Cantor tablets: the content of active drug (minaprine) increased (50 to 100 mg). Therefore, acute intoxication by minaprine can be serious, with generalized seizures, resisting the classic tr... |
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Antidepressant response follows an exponential decay curve: replication and extension.
J. Clin. Psychopharmacol. 17(5) , 426-7, (1997)
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[Three cases of acute agranulocytosis: caused by minaprine?].
Presse Med. 22(2) , 82-3, (1993)
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