2,7-dinitro-9H-fluorene
2,7-dinitro-9H-fluorene structure
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Common Name | 2,7-dinitro-9H-fluorene | ||
|---|---|---|---|---|
| CAS Number | 5405-53-8 | Molecular Weight | 256.214 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 451.5±38.0 °C at 760 mmHg | |
| Molecular Formula | C13H8N2O4 | Melting Point | 330-334°C | |
| MSDS | Chinese USA | Flash Point | 229.9±19.6 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Voltammetric detection of damage to DNA caused by nitro derivatives of fluorene using an electrochemical DNA biosensor.
Anal. Bioanal. Chem 397(1) , 233-41, (2010) An electrochemical DNA biosensor based on the screen printed carbon paste electrode (SPCPE) with an immobilized layer of calf thymus double-stranded DNA has been used for in vitro investigation of the interaction between genotoxic nitro derivatives of fluoren... |
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Preneoplastic lesions and DNA adduct formation of the airborne genotoxic agents 2-nitrofluorene and 2,7-dinitrofluorene.
Carcinogenesis 14(12) , 2627-32, (1993) The urinary mutagenicity (unconjugated forms) after administration of 2,7-dinitrofluorene (2,7-dNF) orally or i.p. was lower compared to 2-nitrofluorene (NF) administration. When partial hepatectomy (PH) was performed before i.p. administration, both substanc... |
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Reductions of nitro and 9-Oxo groups of environmental nitrofluorenes by the rat mammary gland in vitro.
Chem. Res. Toxicol. 13(8) , 793-800, (2000) Nitrofluorenes and C-9-oxidized nitrofluorenes are widespread environmental genotoxins which may be relevant for breast cancer on the basis of their carcinogenicities, particularly of 2, 7-dinitrofluorene (2,7-diNF), for the rat mammary gland. Since their met... |
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DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol.
Chem. Res. Toxicol. 15(4) , 536-44, (2002) Nitrofluorenes are mutagenic and carcinogenic environmental pollutants arising chiefly from combustion of fossil fuels. Nitro aromatic compounds undergo nitroreduction to N-hydroxy arylamines that bind to DNA directly or after O-esterification. This study ana... |
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Potent carcinogenicity of 2,7-dinitrofluorene, an environmental pollutant, for the mammary gland of female Sprague-Dawley rats.
Carcinogenesis 20(10) , 2017-23, (1999) Nitrofluorene compounds are environmental pollutants chiefly from incomplete combustion. This study examined carcinogenicities after one intramammary injection of 2-nitrofluorene (2-NF), 2, 7-dinitrofluorene (2,7-diNF) or dimethyl sulfoxide (DMSO) (solvent co... |
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Tumorigenicity and genotoxicity of an environmental pollutant 2,7-dinitrofluorene after systemic administration at a low dose level to female rats.
Int. J. Cancer 122(9) , 1958-65, (2008) Environmental pollution with nitroaromatic compounds may pose health hazards. We have examined the tumorigenicity in female Sprague-Dawley rats of 2,7-dinitrofluorene (2,7-diNF) and 9-oxo-2,7-diNF administered by intraperitoneal (i.p.) and oral routes at 10 m... |