(-)-Blebbistatin
(-)-Blebbistatin structure
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Common Name | (-)-Blebbistatin | ||
|---|---|---|---|---|
| CAS Number | 856925-71-8 | Molecular Weight | 292.33 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 486.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H16N2O2 | Melting Point | 210-212ºC | |
| MSDS | Chinese USA | Flash Point | 248.1±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1.
J. Physiol. 593(3) , 645-56, (2015) Rac1 regulates stretch-stimulated (i.e. mechanical stress) glucose transport in muscle. Actin depolymerization decreases stretch-induced glucose transport in skeletal muscle. Rac1 is a required part of the mechanical stress-component of the contraction-stimul... |
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Formation of contractile networks and fibers in the medial cell cortex through myosin-II turnover, contraction, and stress-stabilization.
Cytoskeleton (Hoboken.) 72(1) , 29-46, (2015) The morphology of adhered cells depends crucially on the formation of a contractile meshwork of parallel and cross-linked fibers along the contacting surface. The motor activity and minifilament assembly of non-muscle myosin-II is an important component of co... |
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Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.
FASEB J. 24 , 4378-95, (2010) Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular signaling processes. Although the regulation of connexins in GJs has been well characterized, the molecular determinants controlling connexin-hemichannel activity are unresolved.... |
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Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
J. Biol. Chem. , 31183-96, (2008) Glucocorticoids (GCs) play important roles in numerous cellular processes, including growth, development, homeostasis, inhibition of inflammation, and immunosuppression. Here we found that GC-treated human lung carcinoma A549 cells exhibited the enhanced form... |
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Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis.
Development 138 , 1631-41, (2011) Cell elongation is a fundamental process that allows cells and tissues to adopt new shapes and functions. During notochord tubulogenesis in the ascidian Ciona intestinalis, a dramatic elongation of individual cells takes place that lengthens the notochord and... |
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Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle.
J. Physiol. 587 , 155-63, (2009) Each heartbeat is triggered by a pulse of intracellular calcium ions which bind to troponin on the actin-containing thin filaments of heart muscle cells, initiating a change in filament structure that allows myosin to bind and generate force. We investigated ... |
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Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
J. Biol. Chem. , 1514-22, (2009) Recently, we identified a novel signaling pathway involving Epac, Rap, and phospholipase C (PLC)epsilon that plays a critical role in maximal beta-adrenergic receptor (betaAR) stimulation of Ca2+-induced Ca2+ release (CICR) in cardiac myocytes. Here we demons... |
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Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.
Mol. Biol. Cell 20 , 5211-23, (2009) Export of mRNA from the nucleus is linked to proper processing and packaging into ribonucleoprotein complexes. Although several observations indicate a coupling between mRNA 3' end formation and export, it is not known how these two processes are mechanistica... |
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Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis.
Development 137 , 795 - 804, (2010) We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens in a specific sequence, with initia... |
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Roles of formin nodes and myosin motor activity in Mid1p-dependent contractile-ring assembly during fission yeast cytokinesis.
Mol. Biol. Cell 20 , 5195-210, (2009) Two prevailing models have emerged to explain the mechanism of contractile-ring assembly during cytokinesis in the fission yeast Schizosaccharomyces pombe: the spot/leading cable model and the search, capture, pull, and release (SCPR) model. We tested some of... |