Cytidine 5'-monophosphate-N-acetylneuraminic acid
Cytidine 5'-monophosphate-N-acetylneuraminic acid structure
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Common Name | Cytidine 5'-monophosphate-N-acetylneuraminic acid | ||
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| CAS Number | 3063-71-6 | Molecular Weight | 636.433 | |
| Density | 2.02g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H30N4NaO16P | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.
Nat. Commun. 6 , 6651, (2015) Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sialylation influences osteoclast differentiation and subseque... |
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In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity.
PLoS ONE 10 , e0134949, (2015) The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in numerous studies. Fc glycosylation of monoclonal antibodies from current production systems is subject t... |
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A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on generalized modules for membrane antigens (GMMA).
Vaccine 32(23) , 2688-95, (2014) Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing to the burden of disease. Therefore, an affordable vaccine that provides ... |
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Crystal structures of sialyltransferase from Photobacterium damselae.
FEBS Lett. 588(24) , 4720-9, (2014) Sialyltransferase structures fall into either GT-A or GT-B glycosyltransferase fold. Some sialyltransferases from the Photobacterium genus have been shown to contain an additional N-terminal immunoglobulin (Ig)-like domain. Photobacterium damselae α2-6-sialyl... |
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A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice.
Vaccine 33(11) , 1317-23, (2015) The effect of protein-based meningococcal vaccines on prevention of nasopharyngeal colonization has been difficult to investigate experimentally because a reliable animal colonization model did not exist.Human CEACAM1 transgenic mice, which can be colonized b... |
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Characterization of an H9N2 avian influenza virus from a Fringilla montifringilla brambling in northern China.
Virology 476 , 289-97, (2015) Avian H9N2 influenza viruses circulating in domestic poultry populations are occasionally transmitted to humans. We report the genomic characterization of an H9N2 avian influenza virus (A/Brambling/Beijing/16/2012) first isolated from a healthy Fringilla mont... |
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The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.
Oncotarget 6 , 34358-74, (2015) Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal metastatic castration-resistant disease. H... |
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Chemo-enzymatic synthesis of C-9 acetylated sialosides.
Carbohydr. Res. 343(10-11) , 1605-11, (2008) A chemo-enzymatic synthesis of [(5-acetamido-9-O-acetyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-->3)-O-(beta-D-galactopyranosyl)-(1-->3)-O-(2-acetamido-2-deoxy-alpha-D-galactopyranosyl)]-l-serine acetate (1) has been accomplished ... |
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Identification of essential amino acid residues in the hydrophilic loop regions of the CMP-sialic acid transporter and UDP-galactose transporter.
Glycobiology 20(6) , 689-701, (2010) The Golgi CMP-sialic acid transporter (CST) is a type III transmembrane protein with 10 transmembrane domains that are linked by eight hydrophilic loops. To investigate the function of these hydrophilic loops, the green fluorescent protein (GFP) was inserted ... |
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Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.
Biochemistry 47(1) , 320-30, (2008) Sialyltransferases transfer sialic acid from cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NeuAc) to an acceptor molecule. Trans-sialidases of parasites transfer alpha2,3-linked sialic acid from one molecule to another without the involvement of CMP-Ne... |