3063-71-6

3063-71-6 structure

Name: Cytidine 5'-monophosphate-N-acetylneuraminic acid
Chemical Name: CMP-N-acetyl-β-neuraminic acid
CAS Number: 3063-71-6
Molecular Formula: C₂₀H₃₀N₄NaO₁₆P
Molecular Weight: 636.433
Catalog: Research Areas Metabolic Disease
Create Date: 2018-09-01 00:52:58
Modify Date: 2024-01-02 14:00:31
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[1].

Name	CMP-N-acetyl-β-neuraminic acid
Synonyms	CMP-b-D-Sialic Acid,DisodiumSalt CMP-NAN,CMP-NANA,CMP-NeuAc,CMP-Sialic acid CMP-Sia Cytidine-5'-monophospho-N-acetylneuraminic acid disodium salt CMP-N-acetyl-beta-neuraminic acid Cytidine monophosphate n-acetylneuraminic acid cytidine 5-monophospho-N-*acetylneuraminic acid Sodium (2R,4S,5R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-3,4-dihydroxytetrahydro-2-furanyl]methyl phosphate CYTIDINE 5'-MONOPHOSPHO-N- cytidine-5'-monophospho-N-acetyl-D-neuraminic acid cytidine 5'-monophospho-N-acetylneuraminic acid,sodium cmp-nan CMP-N-Acetylneuraminic Acid CMP-sialic acid CMP-Sialic Acid, Monosodium Salt Cytidine 5'-monophosphate-N-acetylneuraminic acid

Description	CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	CMP-Sialic acid (22.5 μM, 45 min) 可用作 CMAH 底物来检测血小板裂解物中 Neu5Gc 的形成[1]。
References	[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45. [3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795.

Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	3