6-Gingerol
6-Gingerol structure
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Common Name | 6-Gingerol | ||
|---|---|---|---|---|
| CAS Number | 23513-14-6 | Molecular Weight | 294.386 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 453.0±35.0 °C at 760 mmHg | |
| Molecular Formula | C17H26O4 | Melting Point | 30 - 32ºC | |
| MSDS | Chinese USA | Flash Point | 159.0±19.4 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.
J. Ethnopharmacol. 156 , 182-9, (2014) Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxi... |
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Integrated LC-MS/MS Analytical Systems and Physical Inspection for the Analysis of a Botanical Herbal Preparation.
Molecules 20 , 10641-56, (2015) The herbal decoction process is generally inconvenient and unpleasant. To avoid using herbal medicine decoctions, various high-quality industrial and pharmaceutical herbal decoction products have been used in clinical applications for more than ten years in T... |
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6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression.
Chem. Biol. Interact. 228 , 69-78, (2015) 6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol to enhance tumor necrosis factor-related apoptosis-inducing... |
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The micronucleus assay in mammalian cells in vitro to assess health benefits of various phytochemicals.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 793 , 79-85, (2015) We evaluated the protective effects of Gentiana lutea extracts (GLEx) and 6-Gingerol (6-G) on clastogenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 7,12-dimethylbenz(α) anthracene (DMBA) in vitro on HepG2 cells using the frequencies of induced mic... |
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Assay of 6-gingerol in CO2 supercritical fluid extracts of ginger and evaluation of its sustained release from a transdermal delivery system across rat skin.
Pharmazie 69(7) , 506-11, (2014) Ginger has been widely used as healthy food condiment as well as traditional Chinese medicine since antiquity. Multiple potentials of ginger for treatment of various ailments have been revealed. However, the biological half-life of 6-gingerol (a principal pun... |
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Inhibitory activity of Socheongryong‑tang and its constituent components against the production of RANTES, eotaxin, eotaxin‑3 and MMP‑9 from BEAS‑2B cells.
Mol. Med. Report. 10(6) , 3035-46, (2014) Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of S... |
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Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells.
Toxicol. Appl. Pharmacol. 279(3) , 253-65, (2014) Glioblastoma multiforme (GBM) is the most lethal and aggressive astrocytoma of primary brain tumors in adults. Although there are many clinical trials to induce the cell death of glioblastoma cells, most glioblastoma cells have been reported to be resistant t... |
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Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.
J. Pharm. Pharmacol. 67(4) , 583-96, (2015) To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and to identify the main UGT enzymes involved in regioselective... |
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Simultaneous determination of 11 major components in Palmul-tang by HPLC-DAD and LC-MS-MS.
J. Chromatogr. Sci. 52(6) , 482-92, (2014) Palmul-tang, a traditional herbal medicine, is composed of eight herbs (Ginseng radix, Glycyrrhizae radix, Hoelen, Atractylodis rhizoma, Angelicae gigantis radix, Cnidii rhizoma, Paeoniae radix and Rehmanniae radix) and exhibits various bioactivities, includi... |
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6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion of CC-chemokine ligand 2 (CCL2) in tumor-associated dendritic cells.
J. Agric. Food Chem. 63(6) , 1730-8, (2015) This study has two novel findings: it is not only the first to demonstrate that tumor-associated dendritic cells (TADCs) facilitate lung and breast cancer metastasis in vitro and in vivo by secreting inflammatory mediator CC-chemokine ligand 2 (CCL2), but it ... |