WAY 200070
WAY 200070 structure
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Common Name | WAY 200070 | ||
|---|---|---|---|---|
| CAS Number | 440122-66-7 | Molecular Weight | 306.11200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H8BrNO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity.
Breast Cancer Res. 13(2) , R43, (2011) The inhibition of estrogen receptor (ER) α action with the ER antagonist tamoxifen is an established treatment in the majority of breast cancers. De novo or acquired resistance to this therapy is common. Expression of ERβ in breast tumors has been implicated ... |
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Antidiabetic actions of an estrogen receptor β selective agonist.
Diabetes 62(6) , 2015-25, (2013) The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 en... |
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Effects of an estrogen receptor alpha agonist on agonistic behaviour in intact and gonadectomized male and female mice.
Psychoneuroendocrinology 36(7) , 981-95, (2011) Gonadal hormones mediate both affiliative and agonistic social interactions. Research in estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice suggests that ERα increases and ERβ decreases male aggression, while the opposite is found for female ERαKO... |
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Effects of a combined treatment with tamoxifen and estrogen receptor β agonists on human breast cancer cell lines.
Arch. Gynecol. Obstet. 289(1) , 163-71, (2014) Coexpression of estrogen receptors (ER) α and β is present in about half of all breast cancer cases. Whereas ERα is a well-established target for endocrine therapy with the selective estrogen receptor modulator tamoxifen, the applicability of ERβ as target in... |
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Modulation of responses to stress by estradiol benzoate and selective estrogen receptor agonists.
J. Endocrinol. 205(3) , 253-62, (2010) Previously, pretreatment with estradiol benzoate (EB) was found to modulate the response of hypothalamic-pituitary-adrenal (HPA) axis and gene expression in several catecholaminergic neuronal locations in ovariectomized (OVX) rats exposed to single immobiliza... |