WAY 200070
WAY 200070 structure
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Common Name | WAY 200070 | ||
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| CAS Number | 440122-66-7 | Molecular Weight | 306.11200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H8BrNO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of WAY 200070WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. |
| Name | 4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one |
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| Synonym | More Synonyms |
| Description | WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. |
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| Related Catalog | |
| Target |
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)[1] |
| In Vivo | Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect[1]. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected[2]. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator[3]. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test[4]. |
| Animal Admin | Rats: Beginning 1 wk after ovariectomy, animals are given a single daily sc injection of hydroxypropyl betacyclodextran [vehicle; 27% (wt/vol) in saline; DPN (2.0 mg/kg), S-DPN (2.0 mg/kg), R-DPN (2.0 mg/kg), WAY-200070-3 (2.0 mg/kg), or PPT (1.0 mg/kg) in a total volume of 0.2 mL. Three hours after the daily treatment injection on d 4-7, animals undergo behavioral testing[4]. Mice: WAY-200070 is dissolved in a 10% ethanol/90% miglyol solution. WAY-200070 or vehicle is injected subcutaneously at a volume of 10 mL/kg body weight. Male ERβKO, ERαKO (both in C57BL/6 background) and WT C57BL/6 mice are injected with vehicle or WAY-200070 (30 mg/kg s.c.). After 15 min, the animals are sacrificed and the striatum is dissected and quickly frozen in liquid nitrogen and stored at -70°C for subsequent assay[1]. |
| References |
| Molecular Formula | C13H8BrNO3 |
|---|---|
| Molecular Weight | 306.11200 |
| Exact Mass | 304.96900 |
| PSA | 66.49000 |
| LogP | 3.66850 |
| Storage condition | 2-8℃ |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319 |
| Precautionary Statements | P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGIII |
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~94%
WAY 200070 CAS#:440122-66-7 |
| Literature: Wyeth Patent: US2003/199562 A1, 2003 ; |
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~94%
WAY 200070 CAS#:440122-66-7 |
| Literature: Wyeth Patent: US2006/46968 A1, 2006 ; Location in patent: Page/Page column 28 ; |
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~0%
WAY 200070 CAS#:440122-66-7 |
| Literature: Barlaam, Bernard; Bernstein, Peter; Dantzman, Cathy; Warwick, Paul Patent: US2004/102435 A1, 2004 ; |
| Precursor 3 | |
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| DownStream 0 | |
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Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity.
Breast Cancer Res. 13(2) , R43, (2011) The inhibition of estrogen receptor (ER) α action with the ER antagonist tamoxifen is an established treatment in the majority of breast cancers. De novo or acquired resistance to this therapy is comm... |
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Antidiabetic actions of an estrogen receptor β selective agonist.
Diabetes 62(6) , 2015-25, (2013) The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as a... |
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Effects of an estrogen receptor alpha agonist on agonistic behaviour in intact and gonadectomized male and female mice.
Psychoneuroendocrinology 36(7) , 981-95, (2011) Gonadal hormones mediate both affiliative and agonistic social interactions. Research in estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice suggests that ERα increases and ERβ decreases ma... |
| 7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol |
| 5-Benzoxazolol,7-bromo-2-(4-hydroxyphenyl) |
| 7-BROMO-2-(4-HYDROXYPHENYL)-1,3-BENZOXAZOL-5-OL |
| 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol |
| 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol |
| WAY-200070 |