440122-66-7
440122-66-7 structure
- Name: WAY 200070
- Chemical Name: 4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one
- CAS Number: 440122-66-7
- Molecular Formula: C13H8BrNO3
- Molecular Weight: 306.11200
- Catalog: Research Areas Neurological Disease
- Create Date: 2017-07-29 04:33:30
- Modify Date: 2024-01-11 17:53:09
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WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
| Name | 4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one |
|---|---|
| Synonyms |
7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol
5-Benzoxazolol,7-bromo-2-(4-hydroxyphenyl) 7-BROMO-2-(4-HYDROXYPHENYL)-1,3-BENZOXAZOL-5-OL 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol WAY-200070 |
| Description | WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)[1] |
| In Vivo | Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect[1]. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected[2]. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator[3]. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test[4]. |
| Animal Admin | Rats: Beginning 1 wk after ovariectomy, animals are given a single daily sc injection of hydroxypropyl betacyclodextran [vehicle; 27% (wt/vol) in saline; DPN (2.0 mg/kg), S-DPN (2.0 mg/kg), R-DPN (2.0 mg/kg), WAY-200070-3 (2.0 mg/kg), or PPT (1.0 mg/kg) in a total volume of 0.2 mL. Three hours after the daily treatment injection on d 4-7, animals undergo behavioral testing[4]. Mice: WAY-200070 is dissolved in a 10% ethanol/90% miglyol solution. WAY-200070 or vehicle is injected subcutaneously at a volume of 10 mL/kg body weight. Male ERβKO, ERαKO (both in C57BL/6 background) and WT C57BL/6 mice are injected with vehicle or WAY-200070 (30 mg/kg s.c.). After 15 min, the animals are sacrificed and the striatum is dissected and quickly frozen in liquid nitrogen and stored at -70°C for subsequent assay[1]. |
| References |
| Molecular Formula | C13H8BrNO3 |
|---|---|
| Molecular Weight | 306.11200 |
| Exact Mass | 304.96900 |
| PSA | 66.49000 |
| LogP | 3.66850 |
| Storage condition | 2-8℃ |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319 |
| Precautionary Statements | P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGIII |
|
~94%
440122-66-7 |
| Literature: Wyeth Patent: US2003/199562 A1, 2003 ; |
|
~94%
440122-66-7 |
| Literature: Wyeth Patent: US2006/46968 A1, 2006 ; Location in patent: Page/Page column 28 ; |
|
~0%
440122-66-7 |
| Literature: Barlaam, Bernard; Bernstein, Peter; Dantzman, Cathy; Warwick, Paul Patent: US2004/102435 A1, 2004 ; |
| Precursor 3 | |
|---|---|
| DownStream 0 | |