NEOPYRITHIAMINE HYDROBROMIDE
NEOPYRITHIAMINE HYDROBROMIDE structure
|
Common Name | NEOPYRITHIAMINE HYDROBROMIDE | ||
|---|---|---|---|---|
| CAS Number | 534-64-5 | Molecular Weight | 420.14300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H20Br2N4O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility.
Alcohol. Clin. Exp. Res. 39 , 2143-53, (2015) Many alcoholics display moderate to severe cognitive dysfunction accompanied by brain pathology. A factor confounded with prolonged heavy alcohol consumption is poor nutrition, and many alcoholics are thiamine deficient. Thus, thiamine deficiency (TD) has eme... |
|
|
Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus.
Appl. Microbiol. Biotechnol. 99 , 10151-61, (2015) The opportunistic human pathogen Aspergillus fumigatus produces numerous different natural products. The genetic basis for the biosynthesis of a number of known metabolites has remained unknown. The gene cluster encoding for the biosynthesis of the conidia-bo... |
|
|
Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells.
Acta Biochim. Pol. 54(2) , 315-22, (2007) Recent evidence suggests that alterations in oxidative metabolism induced by thiamine deficiency lead to neuronal cell death. However, the molecular mechanisms underlying this process are still under extensive investigation. Here, we report that rat pheochrom... |
|
|
Comparative characteristic of thiamine antagonists on apoptosis induction in different types of nerve cell lines.
Ukr. Biokhim. Zh. 80(5) , 76-84, (2008) Abnormalities in oxidative metabolism and inflammation accompany many neurodegenerative diseases. The mechanisms of neurodegeneration induced by thiamine deficiency remain incompletely elucidated. The susceptibility of various types of nerve cells to thiamine... |
|
|
Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen.
Oncotarget 6(8) , 5978-89, (2015) Colony formation is the gold standard assay for determining reproductive cell death after radiation treatment, since effects on proliferation often do not reflect survival. We have developed a high-throughput radiosensitivity screening method based on clonoge... |
|
|
Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages.
PLoS ONE 7(2) , e31223, (2012) Invasive bronchopulmonary aspergillosis (IBPA) is a life-threatening disease in immunocompromised patients. Although Aspergillus terreus is frequently found in the environment, A. fumigatus is by far the main cause of IBPA. However, once A. terreus establishe... |
|
|
Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy.
PLoS Genet. 8 , e1003083, (2012) Chloroquine (CQ) and other quinoline-containing antimalarials are important drugs with many therapeutic benefits as well as adverse effects. However, the molecular targets underlying most such effects are largely unknown. By taking a novel functional genomics... |
|
|
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.
Science 312(5777) , 1208-11, (2006) Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates... |
|
|
Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure.
Biol. Psychiatry 32(10) , 2207-16, (2007) The relative roles of alcohol and thiamine deficiency in causing brain damage remain controversial in alcoholics without the Wernicke-Korsakoff syndrome. Experimental control over alcohol consumption and diet are impossible in humans but can be accomplished i... |
|
|
Reconstitution of a secondary metabolite biosynthetic pathway in a heterologous fungal host.
Methods Mol. Biol. 944 , 175-82, (2012) Expression of multiple genes involved in a particular metabolic pathway in a heterologous host facilitates the study of fungal secondary metabolite biosynthesis and production of useful compounds. Two plasmids with different selection markers, argB and the py... |