2',5'-Dideoxyadenosine
2',5'-Dideoxyadenosine structure
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Common Name | 2',5'-Dideoxyadenosine | ||
|---|---|---|---|---|
| CAS Number | 6698-26-6 | Molecular Weight | 235.24300 | |
| Density | 1.77 g/cm3 | Boiling Point | 547ºC at 760 mmHg | |
| Molecular Formula | C10H13N5O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 284.6ºC | |
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Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.
Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-... |
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A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536.
Mol. Pharmacol. 83(1) , 95-105, (2013) We evaluated the efficacy, potency, and selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell lines constructed to study signaling via three discrete cAMP sensors identified in neuroendocrine cells. SQ22,536 [9-(te... |
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Identification of 17,20β,21-trihydroxy-4-pregnen-3-one (20β-S) receptor binding and membrane progestin receptor alpha on southern flounder sperm (Paralichthys lethostigma) and their likely role in 20β-S stimulation of sperm hypermotility.
Gen. Comp. Endocrinol. 170(3) , 629-39, (2011) The existence of direct progestin actions on teleost sperm to stimulate hypermotility is not widely acknowledged because it has only been demonstrated in members of the family Sciaenidae. In the present study, progestin stimulation of sperm hypermotility was ... |
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Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.
Cancer Res. 70 , 10002-11, (2010) Loss of gap junctional intercellular communication (GJIC) between cancer cells is a common characteristic of malignant transformation. This communication is mediated by connexin proteins that make up the functional units of gap junctions. Connexins are highly... |
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Role of regulator of G-protein signaling 2 (RGS2) in periodontal ligament cells under mechanical stress.
Cell Biochem. Funct. 25(6) , 753-8, (2007) Mechanical stress is thought to regulate the expression of genes in the periodontal ligament (PDL) cells. Using a microarray approach, we recently identified a regulator of G-protein signaling 2 (RGS2) as an up-regulated gene in the PDL cells under compressiv... |
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Phosphoramidate derivatives of 2',5'-dideoxyadenosine as potential inhibitors of the EDHF phenomenon.
Nucleosides Nucleotides Nucleic Acids 24(5-7) , 553-5, (2005) P-site inhibitors of adenyl cyclase, such as the dideoxynucleosides 2',3'-ddA and 2',5-ddA, have been shown to attenuate EDHF phenomenon in rabbit arteries and veins. In order to present the dideoxynucleosides as pre-activated nucleotides and bypass the kinas... |
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Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation.
Int. J. Parasitol. 37(7) , 743-61, (2007) Trichinella spiralis infection causes hyperexcitability in enteric after-hyperpolarising (AH) sensory neurons that is mimicked by neural, immune or inflammatory mediators known to stimulate adenylyl cyclase (AC)/cyclic 3',5'-adenosine monophosphate (cAMP) sig... |
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Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.
J. Cell Physiol. 210(1) , 99-110, (2007) Prostaglandin E(2) (PGE(2)) has been shown to have a strong cytoprotective effect, inhibiting apoptosis. In the present study, we evaluated whether PGE(2) has a protective effect on cigarette smoke extract (CSE)-induced apoptosis in human lung fibroblasts. Ap... |
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Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle.
J. Physiol. 570(Pt 1) , 73-84, (2006) In synthetic phenotype vascular smooth muscle cells (VSMC), activation of epidermal growth factor (EGF) receptor (EGFR) induces a sustained increase in intermediate conductance K(Ca) (int-K(Ca); K(Ca)3.1) channels that is essential for proliferation. However,... |
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Cyclooxygenase-2 induction by bradykinin in aortic vascular smooth muscle cells.
Am. J. Physiol. Heart Circ. Physiol. 290(1) , H30-6, (2006) Vascular smooth muscle cell proliferation and migration play an important role in the pathophysiology of several vascular diseases, including atherosclerosis. Prostaglandins that have been implicated in this process are synthesized by two isoforms of cyclooxy... |