Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Adenosine,2',5'-dideoxy-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

6698-26-6

6698-26-6 structure

Name: 2',5'-Dideoxyadenosine
Chemical Name: 2′,5′-Dideoxyadenosine
CAS Number: 6698-26-6
Molecular Formula: C₁₀H₁₃N₅O₂
Molecular Weight: 235.24300
Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
Create Date: 2018-02-25 08:00:00
Modify Date: 2024-01-03 17:12:36
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

Name	2′,5′-Dideoxyadenosine
Synonyms	2',5'-dideoxyadenosine

Description	2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	IC50: 3 µM (adenylyl cyclase)[1]
In Vitro	2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh)[3]. 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448[3]. 2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively[2]. Western Blot Analysis[3] Cell Line: Primary hippocampal neurons Concentration: 10 μM Incubation Time: 30 min Result: Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
In Vivo	2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats[4]. Animal Model: Male Wistar rats (3-4 months old)[3] Dosage: 0.1 mg/kg Administration: IP; 15 min pre-treated Result: Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats.
References	[1]. Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53. [2]. Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8. [3]. Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631. [4]. Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.

Density	1.77 g/cm3
Boiling Point	547ºC at 760 mmHg
Molecular Formula	C₁₀H₁₃N₅O₂
Molecular Weight	235.24300
Flash Point	284.6ºC
Exact Mass	235.10700
PSA	99.08000
LogP	0.65800
Index of Refraction	1.825
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2934999090

108906-82-7

~72%

6698-26-6

Literature: Desaubry; Shoshani; Johnson Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1453 - 1460

958-09-8

6698-26-6

Literature: Nucleosides and Nucleotides, , vol. 14, # 6 p. 1453 - 1460

Precursor 2
108906-82-7 958-09-8
DownStream 2
36792-88-8 73-24-5

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6698-26-6	14585-60-5
42204-43-3	74625-78-8
28220-20-4	387356-12-9
121878-15-7	851170-89-3
686312-01-6	1809168-60-2