D-AP5(mM/ml)
D-AP5(mM/ml) structure
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Common Name | D-AP5(mM/ml) | ||
|---|---|---|---|---|
| CAS Number | 79055-68-8 | Molecular Weight | 197.126 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 482.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C5H12NO5P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 245.4±31.5 °C | |
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Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.
Antioxid. Redox Signal. 22(9) , 772-84, (2015) Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein (PrP(C)) in neuroprotection. Therefore, the loss of PrP(C) ... |
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Properties of a Glutamatergic Synapse Controlling Information Output from Retinal Bipolar Cells.
PLoS ONE 10 , e0129133, (2015) One general categorization of retinal ganglion cells is to segregate them into tonically or phasically responding neurons, each conveying discrete aspects of the visual scene. Although best identified in the output signals of the retina, this distinction is i... |
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A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus.
J. Neurophysiol. 113 , 2511-23, (2015) The dorsal and ventral hippocampi are functionally and anatomically distinct. Recently, we reported that dorsal Cornu Ammonis area 1 (CA1) neurons have a more hyperpolarized resting membrane potential and a lower input resistance and fire fewer action potenti... |
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Antagonism of ionotropic glutamate receptors attenuates chemical ischemia-induced injury in rat primary cultured myenteric ganglia.
PLoS ONE 9(11) , e113613, (2014) Alterations of the enteric glutamatergic transmission may underlay changes in the function of myenteric neurons following intestinal ischemia and reperfusion (I/R) contributing to impairment of gastrointestinal motility occurring in these pathological conditi... |
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Intracortical Microstimulation (ICMS) Activates Motor Cortex Layer 5 Pyramidal Neurons Mainly Transsynaptically.
Brain Stimul. 8 , 742-50, (2015) Intracortical microstimulation (ICMS) is a technique used for a number of purposes including the derivation of cortical movement representations (motor maps). Its application can activate the output layer 5 of motor cortex and can result in the elicitation of... |
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Novel Striatal GABAergic Interneuron Populations Labeled in the 5HT3a(EGFP) Mouse.
Cereb. Cortex 26 , 96-105, (2015) Histological and morphological studies indicate that approximately 5% of striatal neurons are cholinergic or γ-aminobutyric acidergic (GABAergic) interneurons (gINs). However, the number of striatal neurons expressing known interneuron markers is too small to... |
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Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.
Bioorg. Med. Chem. Lett. 15 , 2279-83, (2005) A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role in t... |
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Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule bassoon.
J. Neurosci. 29(2) , 351-8, (2009) Presynaptic sites typically appear as varicosities (boutons) distributed along axons. Ultrastructurally, presynaptic boutons lack obvious physical barriers that separate them from the axon proper, yet activity-related and constitutive dynamics continuously pr... |
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Ionotropic glutamate receptor GluA4 and T-type calcium channel Cav 3.1 subunits control key aspects of synaptic transmission at the mouse L5B-POm giant synapse.
Eur. J. Neurosci. 42 , 3033-44, (2016) The properties and molecular determinants of synaptic transmission at giant synapses connecting layer 5B (L5B) neurons of the somatosensory cortex (S1) with relay neurons of the posteriomedial nucleus (POm) of the thalamus have not been investigated in mice. ... |
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Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid.
Eur. J. Med. Chem. 42 , 1059-68, (2007) Twelve novel conformationally constrained homologues of glutamic acid have been synthesized and pharmacologically characterized at ionotropic glutamate receptors (iGluRs). Synthesis of the target compounds involved 1,3-dipolar cycloaddition of nitrile oxides ... |