- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: D-AP5(mM/ml)
- Price: Check
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: D-AP5(mM/ml)
- Price: ￥2148.0/5mg
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: D-AP5
- Price: ￥500.0/100mg ￥950.0/250mg ￥1850.0/1g
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: D-AP5
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
79055-68-8
79055-68-8 structure
- Name: D-AP5(mM/ml)
- Chemical Name: (2R)-2-amino-5-phosphonopentanoic acid
- CAS Number: 79055-68-8
- Molecular Formula: C5H12NO5P
- Molecular Weight: 197.126
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2017-06-05 12:29:49
- Modify Date: 2024-01-08 12:47:27
-
D-AP5 is a NMDA receptor antagonist.
| Name | (2R)-2-amino-5-phosphonopentanoic acid |
|---|---|
| Synonyms |
D(-)-APV
UNII:39PJ29YY8Z [3H]-D(-)-2-Amino-5-phosphonopentanoic acid 5-Phosphononorvaline D-2-Amino-5-phosphonovaleric acid D-2-Amino-5-phosphopentanoic acid D-Norvaline,5-phosphono 5-Phosphono-D-norvaline Norvaline, 5-phosphono- 5-PHOSPHONO-DL-NORVALINE D-AP5 D(-)-2-Amino-5-phosphonopentanoic acid |
| Description | D-AP5 is a NMDA receptor antagonist. |
|---|---|
| Related Catalog | |
| Target |
NMDA[1] |
| In Vivo | D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented[1]. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[2]. |
| Animal Admin | Male Lister hooded rats are used in this study. They are housed individually and have free access to food and water at all times except for 12 hr prior to surgery. Animals are implanted with 30 mM D-AP5 (N=6) and tested in the water maze[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 482.1±55.0 °C at 760 mmHg |
| Molecular Formula | C5H12NO5P |
| Molecular Weight | 197.126 |
| Flash Point | 245.4±31.5 °C |
| Exact Mass | 197.045303 |
| PSA | 130.66000 |
| LogP | -2.32 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.536 |