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103680-47-3

103680-47-3 structure
103680-47-3 structure

Name 3-aminopropyl-hydroxy-oxophosphanium
Synonyms 3-Aminopropanephosphinic acid
3-amnopropylphosphonous acid
3-Aminopropylphosphonous acid
Cgp 27 492
Description 3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1].
Related Catalog
In Vitro 3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84 + 0.23 μM), but does not produce an initial contraction[2].
In Vivo 3-Aminopropylphosphinic acid (5 mg/kg; iv) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. Animal Model: guinea pigs[3] Dosage: 5 mg/kg Administration: IV Result: Blocked the inhibitory effects of GABA against vagal broncho-spasm.
References

[1]. [1]Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9.

[2]. [2]Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6.

[3]. [3]Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24.

Molecular Formula C3H10NO2P
Molecular Weight 123.09
Exact Mass 122.03700
PSA 95.92000
Vapour Pressure 0.001mmHg at 25°C

~41%

103680-47-3 structure

103680-47-3

Literature: Queffelec, Clemence; Ribiere, Patrice; Montchamp, Jean-Luc Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8987 - 8991
Precursor  1

DownStream  0