Name | 3-aminopropyl-hydroxy-oxophosphanium |
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Synonyms |
3-Aminopropanephosphinic acid
3-amnopropylphosphonous acid 3-Aminopropylphosphonous acid Cgp 27 492 |
Description | 3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1]. |
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Related Catalog | |
In Vitro | 3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84 + 0.23 μM), but does not produce an initial contraction[2]. |
In Vivo | 3-Aminopropylphosphinic acid (5 mg/kg; iv) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. Animal Model: guinea pigs[3] Dosage: 5 mg/kg Administration: IV Result: Blocked the inhibitory effects of GABA against vagal broncho-spasm. |
References |
Molecular Formula | C3H10NO2P |
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Molecular Weight | 123.09 |
Exact Mass | 122.03700 |
PSA | 95.92000 |
Vapour Pressure | 0.001mmHg at 25°C |
~41% 103680-47-3 |
Literature: Queffelec, Clemence; Ribiere, Patrice; Montchamp, Jean-Luc Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8987 - 8991 |
Precursor 1 | |
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DownStream 0 |