DC Chemicals Limited
China
Product Name: 3-Aminopropylphosphinic acid
Price: $Inquiry/1g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-aminopropylphosphinic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

103680-47-3

103680-47-3 structure

103680-47-3 structure

Name: 3-APPA(CGP 27492)(mM/ml)
Chemical Name: 3-aminopropyl-hydroxy-oxophosphanium
CAS Number: 103680-47-3
Molecular Formula: C₃H₁₀NO₂P
Molecular Weight: 123.09
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-12-12 13:59:42
Modify Date: 2024-01-03 13:50:01
3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1].

Name	3-aminopropyl-hydroxy-oxophosphanium
Synonyms	3-Aminopropanephosphinic acid 3-amnopropylphosphonous acid 3-Aminopropylphosphonous acid Cgp 27 492

Description	3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84 + 0.23 μM), but does not produce an initial contraction[2].
In Vivo	3-Aminopropylphosphinic acid (5 mg/kg; iv) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. Animal Model: guinea pigs[3] Dosage: 5 mg/kg Administration: IV Result: Blocked the inhibitory effects of GABA against vagal broncho-spasm.
References	[1]. [1]Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9. [2]. [2]Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6. [3]. [3]Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24.

Molecular Formula	C₃H₁₀NO₂P
Molecular Weight	123.09
Exact Mass	122.03700
PSA	95.92000
Vapour Pressure	0.001mmHg at 25°C

107-11-9 structure

107-11-9

~41%

103680-47-3 structure

103680-47-3

Literature: Queffelec, Clemence; Ribiere, Patrice; Montchamp, Jean-Luc Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8987 - 8991

Precursor 1
107-11-9
DownStream 0