7-Aminoactinomycin D
7-Aminoactinomycin D structure
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Common Name | 7-Aminoactinomycin D | ||
|---|---|---|---|---|
| CAS Number | 7240-37-1 | Molecular Weight | 1270.432 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1400.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C62H87N13O16 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 801.0±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
PLoS Genet. 10(11) , e1004741, (2014) Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic... |
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Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.
Leuk. Lymphoma 56(3) , 739-47, (2015) The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity and mechanism of a p53 reactivator, ellipticine, in a cellul... |
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Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities.
Infect. Immun. 83(3) , 1030-8, (2015) Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth... |
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An adenoviral vector expressing lipoprotein A, a major antigen of Mycoplasma mycoides subspecies mycoides, elicits robust immune responses in mice.
Vaccine 33(1) , 141-8, (2014) Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides small colony type (MmmSC), is a devastating respiratory disease of cattle. In sub-Saharan Africa, where CBPP is enzootic, live attenuated vaccines are deployed but afford ... |
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Design and Evaluation of Tumor-Specific Dendrimer Epigenetic Therapeutics.
ChemistryOpen 4 , 335-41, (2015) Histone deacetylase inhibitors (HDACi) are promising therapeutics for cancer. HDACi alter the epigenetic state of tumors and provide a unique approach to treat cancer. Although studies with HDACi have shown promise in some cancers, variable efficacy and off-t... |
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The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Biochem. Biophys. Res. Commun. 463 , 545-50, (2015) In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide production, exerted potent anti-proliferative and pro-apop... |
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Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration.
PLoS ONE 10 , e0136620, (2015) ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common neurodegenerative diseases downstream... |
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Macrophage and epithelial cell H-ferritin expression regulates renal inflammation.
Kidney Int. 88 , 95-108, (2015) Inflammation culminating in fibrosis contributes to progressive kidney disease. Cross-talk between the tubular epithelium and interstitial cells regulates inflammation by a coordinated release of cytokines and chemokines. Here we studied the role of heme oxyg... |
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The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines.
Free Radic. Biol. Med. 84 , 22-9, (2015) Reactive oxygen species (ROS) are key modulators of apoptosis and carcinogenesis. One of the important sources of ROS is NADPH oxidases (NOXs). The isoform NOX5 is highly expressed in lymphoid tissues, but it has not been detected in any common Hodgkin or non... |
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MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma.
Oncotarget 6 , 35202-17, (2015) The PI3K/AKT/mTOR axis promotes survival and is a frequently mutated pathway in cancer. Yet, inhibitors targeting this pathway are insufficient to induce cancer cell death as single agents in some contexts, including diffuse large B cell lymphoma (DLBCL). In ... |