7-Aminoactinomycin D

Modify Date: 2024-01-02 18:54:25

7-Aminoactinomycin D Structure
7-Aminoactinomycin D structure
Common Name 7-Aminoactinomycin D
CAS Number 7240-37-1 Molecular Weight 1270.432
Density 1.4±0.1 g/cm3 Boiling Point 1400.8±65.0 °C at 760 mmHg
Molecular Formula C62H87N13O16 Melting Point N/A
MSDS Chinese USA Flash Point 801.0±34.3 °C
Symbol GHS06
GHS06
Signal Word Danger

 Use of 7-Aminoactinomycin D


7-Aminoactinomycin D is a fluorescent DNA stain.

 Names

Name 7-aminoactinomycin D
Synonym More Synonyms

 7-Aminoactinomycin D Biological Activity

Description 7-Aminoactinomycin D is a fluorescent DNA stain.
Related Catalog
References

[1]. Wadkins RM, et al. Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA. Biochemistry. 1991 Oct 1;30(39):9469-78.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1400.8±65.0 °C at 760 mmHg
Molecular Formula C62H87N13O16
Molecular Weight 1270.432
Flash Point 801.0±34.3 °C
Exact Mass 1269.639404
PSA 386.00000
LogP -5.02
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.664
Storage condition 2-8°C
Water Solubility chloroform: 1 mg/mL, clear, red

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU1579000
CHEMICAL NAME :
Actinomycin D, 7-amino-
CAS REGISTRY NUMBER :
7240-37-1
LAST UPDATED :
199409
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C62-H87-N13-O16
MOLECULAR WEIGHT :
1270.62

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
3 umol/L
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,448,1983

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300
Precautionary Statements Missing Phrase - N15.00950417
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+: Very toxic;
Risk Phrases R26/27/28;R36/37/38
Safety Phrases 26-28-36/37-45
RIDADR UN 3462 6
WGK Germany 3
RTECS AU1579000
Packaging Group II
Hazard Class 6.1(a)

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles305

More Articles
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

PLoS Genet. 10(11) , e1004741, (2014)

Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene ...

Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.

Leuk. Lymphoma 56(3) , 739-47, (2015)

The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity a...

Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities.

Infect. Immun. 83(3) , 1030-8, (2015)

Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and r...

 Synonyms

7-Aminodactinomycin
MFCD00077295
7AAD
3H-Phenoxazine-1,9-dicarboxamide, 2,7-diamino-N,N-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4, 
6-dimethyl-3-oxo-
2,7-Diamino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
7-Actinomycin C1
2,7-Diamino-N,N'-bis(6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
3H-Phenoxazine-1,9-dicarboxamide, 2,7-diamino-N,N-bis[(6S,9R,10S,13R,18aS)-hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyc 
lohexadecin-10-yl]-4,6-dimethyl-3-oxo-
7-amino-actinomycin-D
2,7-diamino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
7-amino-AMD
Actinomycin D,7-amino