DEBRISOQUIN SULFATE
DEBRISOQUIN SULFATE structure
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Common Name | DEBRISOQUIN SULFATE | ||
|---|---|---|---|---|
| CAS Number | 581-88-4 | Molecular Weight | 224.27 | |
| Density | N/A | Boiling Point | 309.8ºC at 760 mmHg | |
| Molecular Formula | C10H13N3.1/2H2O4S | Melting Point | 278-280°, 284-285° or 266-268° (H2O) | |
| MSDS | Chinese USA | Flash Point | 141.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma.
BMC Genomics 16 Suppl 1 , S1, (2015) Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths worldwide with less than a 6% 5-year survival rate. PDAC is associated with poor prognosis based on the late stage diagnosis of the disease. Current diagnostic tests lack the... |
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A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90.
Radiat. Res. 183 , 665-74, (2015) Internal emitters such as Strontium-90 ((90)Sr) pose a substantial health risk during and immediately after a nuclear disaster or detonation of an improvised device. The environmental persistency and potency of (90)Sr calls for urgent development of high-thro... |
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Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation.
Radiat. Res. 184 , 121-33, (2015) Due to concerns surrounding potential large-scale radiological events, there is a need to determine robust radiation signatures for the rapid identification of exposed individuals, which can then be used to guide the development of compact field deployable in... |
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Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation.
Radiat. Res. 181(4) , 350-61, (2014) The emergence of the threat of radiological terrorism and other radiological incidents has led to the need for development of fast, accurate and noninvasive methods for detection of radiation exposure. The purpose of this study was to extend radiation metabol... |
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Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone.
Mol. Pharmacol. 89 , 1-13, (2015) Dronedarone is an antiarrhythmic agent approved in 2009 for the treatment of atrial fibrillation. An in-house preliminary study demonstrated that dronedarone inhibits cytochrome P450 (CYP) 3A4 and 3A5 in a time-dependent manner. This study aimed to investigat... |
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Cytochrome P450IID subfamily in non-human primates. Catalytical and immunological characterization.
Biochem. Pharmacol. 41 , 1657, (1991) Interindividual variations of debrisoquine metabolism was recently identified in non-human primates tested in vivo. The catalytical and immunological characterization of cytochrome P450IID subfamily was undertaken in hepatic microsomes from extensive metaboli... |
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Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative. Similarity with the oxidation of arginine to citrulline and nitric oxide.
Biochem. Pharmacol. 46 , 2249, (1993) The microsomal N-hydroxylation of the strongly basic guanidinium group (debrisoquine) to N-hydroxyguanidine (N-hydroxydebrisoquine) and the retroreduction of the N-hydroxyguanidine are demonstrated for the first time. The reduction of the N-hydroxyguanidine b... |
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Gas chromatography/mass spectrometry assays for the determination of debrisoquine and sparteine metabolites in microsomal fractions of rat liver.
Anal. Biochem. 203 , 348, (1992) Debrisoquine and sparteine are prototype substrates of a genetic deficiency in cytochrome P450-dependent drug metabolism. Sensitive assays of in vitro oxidation of sparteine and debrisoquine are required for evaluation of this polymorphism. The activities wer... |
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Studies on the properties of some peripheral MAO inhibitors.
Prog. Neuropsychopharmacol. Biol. Psychiatry 15 , 297, (1991) 1. Studies were carried out on three monoamine oxidase (MAO) inhibitors, two of which, debrisoquine and para- hydroxyphenelzine, are purported to be peripheral inhibitors and one, phenelzine, is a peripherally acting inhibitor, which has been included for com... |
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Influence of gamma-aminobutyric acid on the changes of blood pressure in rats.
Korean J. Intern. Med. 5 , 23-33, (1991) This is an attempt to investigate the effect of gamma-aminobutyric acid (GABA), a well-known major inhibitory neurotransmitter in the central nervous system, on the blood pressure response in rats and to elucidate the mechanism of its action. GABA injected in... |