Olprinone (Hydrochloride)
Olprinone (Hydrochloride) structure
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Common Name | Olprinone (Hydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 119615-63-3 | Molecular Weight | 286.72 | |
| Density | 1.34g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H11ClN4O | Melting Point | >300ºC | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury.
Adv. Exp. Med. Biol. 756 , 189-96, (2013) Inflammation, oxidation, lung edema, and other factors participate in surfactant dysfunction in meconium aspiration syndrome (MAS). Therefore, we hypothesized that anti-inflammatory treatment may reverse surfactant dysfunction in the MAS model. Oxygen-ventila... |
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Olprinone attenuates the development of ischemia/reperfusion injury of the gut.
Intensive Care Med. 36(7) , 1235-47, (2010) Splanchnic artery occlusion (SAO) shock is a severe form of circulatory shock produced by ischemia and reperfusion of the splanchnic organs. The occlusion and reperfusion of the splanchnic arteries causes activation and adhesion of polymorphonuclear neutrophi... |
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Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.
Pharmacol. Res. 64(1) , 68-79, (2011) Olprinone is a specific phosphodiesterase (PDE)-III inhibitor, which has been found to have anti-inflammatory effects in addition to its main inotropic and peripheral vasodilatory effects. In the present study we investigated the effects of olprinone (0.2mg/k... |
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The effects of the phosphodiesterase inhibitor olprinone on global cerebral ischemia.
Anesth. Analg. 110(3) , 888-94, (2010) The phosphodiesterase III inhibitor olprinone has been confirmed to improve myocardial function and increase cerebral blood flow; therefore, if olprinone exerts direct neuroprotective effects against global cerebral ischemia to the same degree as cilostazol, ... |
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Intermittent infusions of carperitide or inotoropes in out-patients with advanced heart failure.
J. Cardiol. 59(3) , 366-73, (2012) The ambulatory treatment of advanced heart failure (HF) with intermittent infusions of inotropes or natriuretic peptide chosen immediately before each infusion has not been described.Between May 2005 and July 2009, we treated 11 patients presenting with advan... |
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Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs.
Eur. J. Anaesthesiol. 28(7) , 519-24, (2011) Phosphodiesterase 3 (PDE3) inhibitors and sevoflurane are both known to have bronchodilator properties and the combination of these two agents may be synergistic. We tested this hypothesis in a model of airway hyperresponsiveness using ovalbumin-sensitised gu... |
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Determination of olprinone in human plasma utilizing liquid chromatography tandem mass spectrometry.
J. Pharm. Biomed. Anal. 54(1) , 198-202, (2011) A sensitive and rapid method was developed for quantification of olprinone in human plasma utilizing liquid chromatography tandem mass spectrometry (LC-MS/MS). An aliquot of 1 mL plasma sample was extracted with ethyl acetate-dichloromethane. Separation of ol... |
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Neuroprotective effects of olprinone after cerebral ischemia/reperfusion injury in rats.
Neurosci. Lett. 503(2) , 93-9, (2011) Olprinone hydrochloride, a specific phosphodiesterase III inhibitor, has anti-inflammatory effects in addition to its inotropic and vasodilatory effects. The purpose of this study was to examine the beneficial effects of olprinone on cerebral ischemia reperfu... |
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Anesthetic management of a patient undergoing liver transplantation who had previous coronary artery bypass grafting using an in situ right gastroepiploic artery.
J. Anesth. 24(2) , 264-7, (2010) We describe successful anesthetic management during living-donor liver transplantation in a 63-year-old man with previous coronary artery bypass grafting (CABG) that employed an in situ right gastroepiploic artery (RGEA). Anesthesia was maintained with 1.5% i... |
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Differential vasodilation response to olprinone in rabbit renal and common carotid arteries.
J. Anesth. 24(1) , 61-6, (2010) Olprinone, one of the most frequently used phosphodiesterase-3 inhibitors, exerts its positive inotropic and vasodilation effects by inhibiting the degradation of intracellular cyclic adenosine monophosphate (cAMP). The vasodilation response to olprinone is n... |