Olprinone (Hydrochloride) structure
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Common Name | Olprinone (Hydrochloride) | ||
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CAS Number | 119615-63-3 | Molecular Weight | 286.72 | |
Density | 1.34g/cm3 | Boiling Point | N/A | |
Molecular Formula | C14H11ClN4O | Melting Point | >300ºC | |
MSDS | USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Olprinone (Hydrochloride)Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. |
Name | 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile,hydrochloride |
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Synonym | More Synonyms |
Description | Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. |
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Related Catalog | |
References |
Density | 1.34g/cm3 |
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Melting Point | >300ºC |
Molecular Formula | C14H11ClN4O |
Molecular Weight | 286.72 |
PSA | 83.18000 |
LogP | 2.60738 |
Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26 |
RIDADR | NONH for all modes of transport |
RTECS | US4201450 |
Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury.
Adv. Exp. Med. Biol. 756 , 189-96, (2013) Inflammation, oxidation, lung edema, and other factors participate in surfactant dysfunction in meconium aspiration syndrome (MAS). Therefore, we hypothesized that anti-inflammatory treatment may reve... |
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Olprinone attenuates the development of ischemia/reperfusion injury of the gut.
Intensive Care Med. 36(7) , 1235-47, (2010) Splanchnic artery occlusion (SAO) shock is a severe form of circulatory shock produced by ischemia and reperfusion of the splanchnic organs. The occlusion and reperfusion of the splanchnic arteries ca... |
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Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.
Pharmacol. Res. 64(1) , 68-79, (2011) Olprinone is a specific phosphodiesterase (PDE)-III inhibitor, which has been found to have anti-inflammatory effects in addition to its main inotropic and peripheral vasodilatory effects. In the pres... |
E 1020 |
pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride |
Olprinone hydrochloride |
Olprinone (Hydrochloride) |
1,2-dihydro-5-imidazo<1,2-a>pyridin-6-yl-6-methyl-2-oxo-3-pyridine carbonitrile hydrochloride |
1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride |
MFCD01749474 |
Loprinone hydrochloride |