Disodium 2'-deoxy-5'-O-phosphonatouridine
Disodium 2'-deoxy-5'-O-phosphonatouridine structure
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Common Name | Disodium 2'-deoxy-5'-O-phosphonatouridine | ||
|---|---|---|---|---|
| CAS Number | 42155-08-8 | Molecular Weight | 352.146 | |
| Density | 1.742 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H11N2Na2O8P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877 , 2937-2944, (2009) To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography–tandem mass spectrometry (LC-MS/MS). This assay allowed the determination of: ... |
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Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.
Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8924-9, (2013) In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride donor. Because all three substrates bind in close proximity to ... |
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Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.
J. Neurosci. 28 , 7219-7230, (2008) Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficiency has been implicated in the pathogenesis of psychiatric ... |
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Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1.
Protein Sci. 20(8) , 1398-410, (2011) Thymidylate synthase X (ThyX) catalyzes the methylation of dUMP to form dTMP in bacterial life cycle and is regarded as a promising target for antibiotics discovery. Helicobacter pylori is a human pathogen associated with a number of human diseases. Here, we ... |
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QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.
J. Phys. Chem. A 113(10) , 2176-82, (2009) Thymidylate synthase (TS) is an enzyme that catalyzes a complex cascade of reactions. A theoretical study of the reduction of an exocyclic methylene intermediate by hydride transfer from the 6S position of 5,6,7,8-tetrahydrofolate (H(4)folate), to form 2'-deo... |
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Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase.
J. Comput. Aided Mol. Des. 27(1) , 45-66, (2013) Tyrosine nitration is a widespread post-translational modification capable of affecting both the function and structure of the host protein molecule. Enzyme thymidylate synthase (TS), a homodimer, is a molecular target for anticancer therapy. Recently purifie... |
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A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link.
Chem. Commun. (Camb.) (16) , 1781-3, (2006) An unexpected substrate-dependent lag-phase, found in the single turnover reduction of FDTS bound flavin, sheds light on the molecular mechanism of this alternative thymidylate synthase. |
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2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.
J. Med. Chem. 56(22) , 9356-60, (2013) Thymidylate synthase (TS) is a target for antifolate-based chemotherapies of microbial and human diseases. Here, ligand-based, synthetic, and X-ray crystallography studies led to the discovery of 6-(3-cyanobenzoyloxy)-2-oxo-2H-naphto[1,8-bc]furan, a novel inh... |
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Novel positron emission tomography tracer distinguishes normal from cancerous cells.
J. Biol. Chem. 286(39) , 33872-8, (2011) Development of tumor-specific probes for imaging by positron emission tomography has broad implications in clinical oncology, such as diagnosis, staging, and monitoring therapeutic responses in patients, as well as in biomedical research. Thymidylate synthase... |
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Simultaneous determination of genomic DNA methylation and uracil misincorporation.
Med. Princ. Pract. 18(2) , 81-4, (2009) To develop a method for the simultaneous measurement of 5-methylcytosine (5-metC) and 2'-deoxyuridine monophosphate (dU).Genomic DNA was extracted from the HepG2 cell line grown in experimental complete medium or in folate-depleted medium. Samples were treate... |