Chemical Communications 2006-04-28

A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link.

Aaron Mason, Nitish Agrawal, M Todd Washington, Scott A Lesley, Amnon Kohen

Index: Chem. Commun. (Camb.) (16) , 1781-3, (2006)

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Abstract

An unexpected substrate-dependent lag-phase, found in the single turnover reduction of FDTS bound flavin, sheds light on the molecular mechanism of this alternative thymidylate synthase.