Clozapine N-oxide
Clozapine N-oxide structure
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Common Name | Clozapine N-oxide | ||
|---|---|---|---|---|
| CAS Number | 34233-69-7 | Molecular Weight | 342.823 | |
| Density | 1.36g/cm3 | Boiling Point | 517.4ºC at 760mmHg | |
| Molecular Formula | C18H19ClN4O | Melting Point | 190-248ºC | |
| MSDS | Chinese USA | Flash Point | 266.7ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks.
J. Clin. Invest. 123(12) , 5342-50, (2013) The ability to map the functional connectivity of discrete cell types in the intact mammalian brain during behavior is crucial for advancing our understanding of brain function in normal and disease states. We combined designer receptor exclusively activated ... |
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Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression.
J. Clin. Invest. 123(12) , 5334-41, (2013) Negative affect is critical for conferring vulnerability to opiate addiction as reflected by the high comorbidity of opiate abuse with major depressive disorder (MDD). Rodent models implicate amygdala prodynorphin (Pdyn) as a mediator of negative affect; howe... |
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Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
J. Med. Chem. 52 , 4266-76, (2009) The cardiac hERG K(+) channel constitutes a long-standing and expensive antitarget for the drug industry. From a study of the flexibility of hERG around its internal binding cavity, we have developed a new structural model of drug binding to hERG, which invol... |
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Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion.
J. Neurosci. 35(11) , 4582-6, (2015) Conditioned taste aversion (CTA) is a phenomenon in which an individual forms an association between a novel tastant and toxin-induced gastrointestinal malaise. Previous studies showed that the parabrachial nucleus (PBN) contains neurons that are necessary fo... |
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Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.
Nat. Neurosci. 16(5) , 632-8, (2013) A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We fou... |
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Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.
J. Neurosci. 34(18) , 6352-66, (2014) Dopamine neurons in the ventral tegmental area (VTA) govern reward and motivation and dysregulated dopaminergic transmission may account for anhedonia and other symptoms of depression. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine ki... |
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Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.
Proc. Natl. Acad. Sci. U. S. A. 111(16) , 5896-901, (2014) Directed migration of diverse cell types plays a critical role in biological processes ranging from development and morphogenesis to immune response, wound healing, and regeneration. However, techniques to direct, manipulate, and study cell migration in vitro... |
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Independent hypothalamic circuits for social and predator fear.
Nat. Neurosci. 16(12) , 1731-3, (2013) The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essen... |
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Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
J. Pharmacol. Exp. Ther. 268 , 1403, (1994) The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 (5-HT6) and rat 5-hydroxytryptamine-7 (5-HT7) receptors in transiently expressed COS-7 cells (5-HT7) or stably transfected HEK-293 cel... |
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Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites.
J. Pharm. Sci. 83 , 1412, (1994) Pooled plasma from healthy volunteers was spiked with pure, synthetic clozapine or clozapine N-oxide and then made alkaline with either sodium hydroxide or sodium carbonate. The alkalized samples were allowed to stand at room temperature for various time inte... |