Clozapine N-oxide

Modify Date: 2024-01-03 16:42:04

Clozapine N-oxide structure	Common Name	Clozapine N-oxide
	CAS Number	34233-69-7	Molecular Weight	342.823
	Density	1.36g/cm3	Boiling Point	517.4ºC at 760mmHg
	Molecular Formula	C₁₈H₁₉ClN₄O	Melting Point	190-248ºC
	MSDS	Chinese USA	Flash Point	266.7ºC
	Symbol	GHS06	Signal Word	Danger

Use of Clozapine N-oxide

Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.

Name	clozapine n-oxide
Synonym	More Synonyms

Description	Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Target	DREADD[1]
In Vivo	After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Acutely administered CNO can be metabolically converted to Clozapine in other species such as human and guinea-pig. The metabolites that may form after chronic administration of CNO to DREADD-expressing mice (or other species) have not been studied systematically. However, even if back-transformation to Clozapine occurs after chronic CNO administration, it should be noted that Clozapine is a more potent (by ~10-fold) DREADD agonist than CNO itself. Moreover, confounding biological effects of potential CNO metabolites can be easily identified by including both saline- and CNO-treated WT animals in a particular DREADD study. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h). One possibility is that CNO tends to accumulate in tissues, although other scenarios are also feasible[1]. Using a general pharmacokinetic model for the interconversion process, the mean total clearances of Clozapine and Clozapine N-oxide (CNO) are 28.45 L/hr and 45.30 L/hr, respectively[2].
References	[1]. Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. [2]. Chang WH, et al. Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):723-39.

Density	1.36g/cm3
Boiling Point	517.4ºC at 760mmHg
Melting Point	190-248ºC
Molecular Formula	C₁₈H₁₉ClN₄O
Molecular Weight	342.823
Flash Point	266.7ºC
Exact Mass	342.124725
PSA	57.06000
LogP	0.76
Index of Refraction	1.685
Storage condition	2-8℃

Clozapine N-oxide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP1760000

CHEMICAL NAME :: 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide

CAS REGISTRY NUMBER :: 34233-69-7

LAST UPDATED :: 198706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H19-Cl-N4-O

MOLECULAR WEIGHT :: 342.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 43,309,1978

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	22-36/37/38
Safety Phrases	26-36
RIDADR	UN 2811 6.1/PG 3
RTECS	HP1760000
Packaging Group	III
Hazard Class	6.1(b)

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8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide

8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-

Clozapine N-oxide

Clozapine (N-oxide)

DC Chemicals Limited
China
Product Name: CLOZAPINE N-OXIDE
Price: $450.0/100mg $800.0/250mg $1450.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CLOZAPINE N-OXIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $79/10mM*1mLinDMSO

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Clozapine N-oxide

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