Clozapine N-oxide
Names
[ CAS No. ]:
34233-69-7
[ Name ]:
Clozapine N-oxide
[Synonym ]:
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
Clozapine N-oxide
Clozapine (N-oxide)
Biological Activity
[Description]:
[Related Catalog]:
[Target]
DREADD[1]
[In Vivo]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.36g/cm3
[ Boiling Point ]:
517.4ºC at 760mmHg
[ Melting Point ]:
190-248ºC
[ Molecular Formula ]:
C18H19ClN4O
[ Molecular Weight ]:
342.823
[ Flash Point ]:
266.7ºC
[ Exact Mass ]:
342.124725
[ PSA ]:
57.06000
[ LogP ]:
0.76
[ Index of Refraction ]:
1.685
[ Storage condition ]:
2-8℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP1760000
- CHEMICAL NAME :
- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide
- CAS REGISTRY NUMBER :
- 34233-69-7
- LAST UPDATED :
- 198706
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C18-H19-Cl-N4-O
- MOLECULAR WEIGHT :
- 342.86
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 43,309,1978
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H319-H335
[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
22-36/37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
UN 2811 6.1/PG 3
[ RTECS ]:
HP1760000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
J. Clin. Invest. 123(12) , 5342-50, (2013)
The ability to map the functional connectivity of discrete cell types in the intact mammalian brain during behavior is crucial for advancing our understanding of brain function in normal and disease s...
Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression.J. Clin. Invest. 123(12) , 5334-41, (2013)
Negative affect is critical for conferring vulnerability to opiate addiction as reflected by the high comorbidity of opiate abuse with major depressive disorder (MDD). Rodent models implicate amygdala...
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.J. Med. Chem. 52 , 4266-76, (2009)
The cardiac hERG K(+) channel constitutes a long-standing and expensive antitarget for the drug industry. From a study of the flexibility of hERG around its internal binding cavity, we have developed ...