HELSS
HELSS structure
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Common Name | HELSS | ||
|---|---|---|---|---|
| CAS Number | 88070-98-8 | Molecular Weight | 317.177 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 467.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H13BrO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 236.2±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.
J. Neurosci. 35 , 8593-603, (2015) Nerve growth factor (NGF) is elevated in certain chronic pain conditions and is a sufficient stimulus to cause lasting pain in humans, but the actual mechanisms underlying the persistent effects of NGF remain incompletely understood. We developed a rat model ... |
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Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration.
PLoS ONE 10 , e0143277, (2015) Calcium independent group VIA phospholipase A2 (iPLA2β) and Matrix Metalloproteinase-9 (MMP-9) are upregulated in many disease states; their involvement with cancer cell migration has been a recent subject for study. Further, the molecular mechanisms mediatin... |
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Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.
J. Neuroinflammation 12 , 199, (2015) Oxidative stress and inflammation are important factors contributing to the pathophysiology of numerous neurological disorders, including Alzheimer's disease, Parkinson's disease, acute stroke, and infections of the brain. There is well-established evidence t... |
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Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells.
Biol. Chem. 396(2) , 153-62, (2015) We analyzed signaling mechanisms for prostaglandin E2 (PGE2) production following activation of proteinase-activated receptor-1 (PAR1), a thrombin receptor, in preosteoblastic MC3T3-E1 cells. PAR1 stimulation caused PGE2 release, an effect suppressed by inhib... |
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Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.
Cell Calcium 46(1) , 65-72, (2009) In vascular smooth muscle, KCl not only elevates intracellular free Ca(2+) ([Ca(2+)](i)), myosin light chain kinase activity and tension (T), but also can inhibit myosin light chain phosphatase activity by activation of rhoA kinase (ROCK), resulting in Ca(2+)... |
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The absence of myocardial calcium-independent phospholipase A2γ results in impaired prostaglandin E2 production and decreased survival in mice with acute Trypanosoma cruzi infection.
Infect. Immun. 81(7) , 2278-87, (2013) Cardiomyopathy is a serious complication of Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi. The parasite often infects cardiac myocytes, causing the release of inflammatory mediators, including eicosanoids. A recent study from our laborat... |
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Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells.
Vascul. Pharmacol. 71 , 116-26, (2015) This work is to investigate the role of CRF receptors in VSMC migration and the relevant mechanisms. We studied the role of CRF receptors in cell motility and found that S1P signaling pathway is involved in the regulation of cPLA2 induced by CRF. S1P is synth... |
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Role of phospholipase A(2) in retrograde transport of ricin.
Toxins (Basel.) 3(9) , 1203-19, (2011) Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a disulfide bond to a cell binding B-chain. After internaliza... |
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Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.
Am. J. Pathol. 179(1) , 452-61, (2011) We and others have shown that calcium-independent phospholipase A(2) (iPLA(2)) is involved in epithelial ovarian cancer (EOC). Hence, we propose that iPLA(2) is a potential effective and novel target for EOC. We tested this concept and found that bromoenol la... |
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Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes.
Br. J. Dermatol. 158(1) , 31-7, (2008) In many cells, depletion of intracellular calcium (Ca2+) reservoirs triggers Ca2+ entry through store-operated Ca2+ channels in the plasma membrane. However, the mechanisms of agonist-induced calcium entry (ACE) in keratinocytes are not fully understood.This ... |