88070-98-8

88070-98-8 structure

Name: HELSS
Chemical Name: (6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
CAS Number: 88070-98-8
Molecular Formula: C₁₆H₁₃BrO₂
Molecular Weight: 317.177
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2018-06-18 23:33:21
Modify Date: 2024-01-05 17:39:54
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].

Name	(6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
Synonyms	Haloenol lactone suicide substrate MFCD00270871 bromoenol lactone 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (6Z)- 6-Btnpo L66J B- FT6VOYTJ CU1E HELSS BEL (6Z)-6-(Bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one BTNP

Description	Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Others
Target	PLA2:7 μM (IC50)
In Vitro	In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilised mast cells where Ca2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signalling, both the release from internal stores and sustained elevation due to Ca2+ influx[1].
References	[1]. Fensome-Green A, et al. Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. Cell Calcium. 2007 Feb;41(2):145-53. [2]. Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121(6):1018-24.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport