HELSS
HELSS structure
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Common Name | HELSS | ||
|---|---|---|---|---|
| CAS Number | 88070-98-8 | Molecular Weight | 317.177 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 467.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H13BrO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 236.2±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of HELSSBromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2]. |
| Name | (6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PLA2:7 μM (IC50) |
| In Vitro | In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilised mast cells where Ca2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signalling, both the release from internal stores and sustained elevation due to Ca2+ influx[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 467.0±45.0 °C at 760 mmHg |
| Molecular Formula | C16H13BrO2 |
| Molecular Weight | 317.177 |
| Flash Point | 236.2±28.7 °C |
| Exact Mass | 316.009888 |
| PSA | 26.30000 |
| LogP | 4.36 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.716 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
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Bromoenol Lactone Attenuates Nicotine-Induced Breast Cancer Cell Proliferation and Migration.
PLoS ONE 10 , e0143277, (2015) Calcium independent group VIA phospholipase A2 (iPLA2β) and Matrix Metalloproteinase-9 (MMP-9) are upregulated in many disease states; their involvement with cancer cell migration has been a recent su... |
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Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.
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| Haloenol lactone suicide substrate |
| MFCD00270871 |
| bromoenol lactone |
| 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (6Z)- |
| 6-Btnpo |
| L66J B- FT6VOYTJ CU1E |
| HELSS |
| BEL |
| (6Z)-6-(Bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one |
| BTNP |