Milrinone
Milrinone structure
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Common Name | Milrinone | ||
|---|---|---|---|---|
| CAS Number | 78415-72-2 | Molecular Weight | 211.219 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 448.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H9N3O | Melting Point | >3000C | |
| MSDS | USA | Flash Point | 225.2±28.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.
J. AOAC Int. 97(6) , 1526-37, (2015) A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zor... |
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Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.
Hypertension 66 , 800-8, (2015) Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the protein kinase A-mediated phosphorylation of phosphodiesterase 3... |
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Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets.
J. Thromb. Haemost. 12(10) , 1733-43, (2014) Dissecting the signaling events that contribute to platelet activation will increase our understanding of platelet function and aid in the development of new antiplatelet agents. However, high-throughput methodology for the quantitative analysis of platelet s... |
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Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles.
Endocrinology 156(4) , 1464-76, (2015) In this study, we explored the effects of oocytic phosphoinositide 3-kinase (PI3K) activation on folliculogensis by generating transgenic mice, in which the oocyte-specific Cre-recombinase induces the expression of constitutively active mutant PI3K during the... |
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A new and fast strategy based on semiautomatic microextraction by packed sorbent followed by ultra high performance liquid chromatography for the analysis of drugs and their metabolites in human urine.
J. Sep. Sci. 37(22) , 3314-5, (2014) A novel analytical approach has been developed for the determination of selected drugs (milrinone, enalapril, carvedilol, spironolactone, acenocumarol, ticlopidine, cilazapril) and their metabolites (2-oxoticlopidine, cilazaprilat, canrenone, 5'-hydroxycarved... |
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Expression and characterization of three Aurora kinase C splice variants found in human oocytes.
Mol. Hum. Reprod. 21 , 633-44, (2015) Chromosome segregation is an extensively choreographed process yet errors still occur frequently in female meiosis, leading to implantation failure, miscarriage or offspring with developmental disorders. Aurora kinase C (AURKC) is a component of the chromosom... |
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Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3).
FASEB J. 27(11) , 4419-28, (2013) The ectoenzyme CD39 suppresses thrombosis and inflammation by suppressing ATP and ADP to AMP. However, mechanisms of CD39 transcriptional and post-translational regulation are not well known. Here we show that CD39 levels are modulated by inhibition of phosph... |
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Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model.
Crit. Care 19 , 241, (2015) Esmolol may efficiently reduce heart rate (HR) and decrease mortality during septic shock. An improvement of microcirculation dissociated from its macrocirculatory effect may a role. The present study investigated the effect of esmolol on gut and sublingual m... |
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A Bayesian network meta-analysis on the effect of inodilatory agents on mortality.
Br. J. Anaesth. 114 , 746-56, (2015) Inodilators are commonly used in critically ill patients, but their effect on survival has not been properly studied to date. The objective of this work was to conduct a network meta-analysis on the effects of inodilators on survival in adult cardiac surgery ... |
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Effects of milrinone and epinephrine or dopamine on biventricular function and hemodynamics in an animal model with right ventricular failure after pulmonary artery banding.
Am. J. Physiol. Heart Circ. Physiol. 309 , H206-12, (2015) Right ventricular (RV) failure due to chronic pressure overload is a main determinant of outcome in congenital heart disease. Medical management is challenging because not only contractility but also the interventricular relationship is important for increasi... |