Name | milrinone |
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Synonyms |
6-Hydroxy-2-methyl-3,4'-bipyridine-5-carbonitrile
EINECS 278-903-6 MFCD00133539 1,6-dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile Milrinonum 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile Milrila Milrinone 1,2-Dihydro-6-methyl-2-oxo-5-(4-pyridinyl)nicotinonitrile 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile [3,4'-Bipyridine]-5-carbonitrile, 6-hydroxy-2-methyl- Corotrope Milrinona Primacor Corotrop 2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile [3,4'-Bipyridine]-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo- |
Description | Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator. |
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Related Catalog | |
In Vitro | Milrinone (1 µM) increases PKA activity in hypoxic myocytes to normoxic levels. Milrinone (50 nM) normalizes TP receptor sensitivity in hypoxic myocytes by restoring PKA-mediated regulatory TP receptor phosphorylation[1]. Milrinone significantly reduces NE-induced vasoconstriction, attenuating both NE sensitivity and maximal tension generation. Inhibition of ATP-sensitive K+ channels or voltage-gated K+ channels do not prevent the milrinone-induced attenuation of NE responses[4]. |
In Vivo | Milrinone (1 μg/kg/min, i.v.) significantly reduces PAP, PVR (−18.96 ± 1.7%), and LAP (−26.03 ± 2.3%) in congestive heart failure (CHF) rats. Milrinone (1 mg/mL, inhalation) results in a near-maximal reduction of PAP without significant effects on AP, decreases pulmonary artery pressure similarly in a larger collective of CHF rats. Milrinone inhalation selectively increases cAMP but not cGMP plasma concentrations in both groups. Repeated milrinone inhalations even reduce lung wet/dry weight ratio[2]. Milrinone (49.5 μg) largely shifts the ESPVR upwards and significantly increases end-systolic pressure (ESP(0.08)) and the systolic pressure-volume area (PVA(0.08)) at a mid-range LV volume (0.08 mL/g myocardium). Milrinone also slightly decreases LV ESP(ESV) and decreased Ea[3]. |
Animal Admin | In juvenile rats of 100 ± 8 g body weight (bw), CHF is induced by supracoronary aortic banding. In brief, rats are anesthetized by intraperitoneal injection of ketamine (87 mg/kg bw) and xylazine (13 mg/kg bw). Rats are placed in the supine position, the chest wall is shaved, and a left thoracotomy is performed in the third intercostal space during ventilation with 100% O2. The ascending aorta is freed from connective tissue and partially occluded by implantation of a titanium clip with a defined internal diameter of 0.8 mm. After surgical closure of the thorax, the rats are allowed to recover from anesthesia. For postoperative analgesia, rats receive 250 mg/kg bw of metamizole intramuscularly immediately after the operation and on the first postoperative day. Sham-operated rats serve as controls. After recovery from anesthesia, the animals are placed in cages with free access to water and standard laboratory diet. For inhalation, milrinone (0.2-5 mg/mL) or NaCl (0.9%) are nebulized using an ultrasonic nebulizer and inhaled for 3 min at identical peak inspiratory pressures as used throughout the experiment. A 3-min nebulization of 1 mg/mL milrinone results in vaporization of 14 μg of the phosphodiesterase-3 inhibitor as determined by microgravimetry. Therefore, the respective dose of 39 μg/kg is analog to inhaled doses in human studies. For intravenous delivery, milrinone (initial bolus of 2-10 μg/kg, followed by 0.2-1 μg/kg/min) or equivalent volumes of NaCl (0.9%; initial bolus of 1.6 mL/kg, followed by 10 μL/kg/h) are administered by an infusion pump for 10 min. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 448.7±45.0 °C at 760 mmHg |
Melting Point | >3000C |
Molecular Formula | C12H9N3O |
Molecular Weight | 211.219 |
Flash Point | 225.2±28.7 °C |
Exact Mass | 211.074554 |
PSA | 69.54000 |
LogP | 0.41 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.622 |
Storage condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Water Solubility | DMSO: >10 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 + H311 + H331 |
Precautionary Statements | Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T:Toxic |
Risk Phrases | R23/24/25 |
Safety Phrases | S36/37/39-S45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | DW1762000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2933399090 |
Precursor 9 | |
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DownStream 2 | |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |