Leonurine
Leonurine structure
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Common Name | Leonurine | ||
|---|---|---|---|---|
| CAS Number | 24697-74-3 | Molecular Weight | 311.334 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 496.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C14H21N3O5 | Melting Point | 191-193ºC | |
| MSDS | Chinese USA | Flash Point | 254.2±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Leonurus japonicus, Leonurus cardiaca, Leonotis leonurus: a novel HPLC study on the occurrence and content of the pharmacologically active guanidino derivative leonurine.
Pharmazie 67(12) , 973-9, (2012) Leonurine is a prominent pharmacologically active guanidine alkaloid (4-{[amino(imino)methyl]amino} butyl-4-hydroxy-3,5-dimethoxybenzoate), mainly exerting cardiovascular, hypotensive, uterotonic, and neuroprotective effects. It is commonly regarded as the pr... |
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Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS.
J. Pharm. Biomed. Anal. 76 , 192-9, (2013) A simple, sensitive and specific method was developed for simultaneous determination of stachydrine and leonurine in rat plasma using diphenhydramine as an internal standard (IS). The separation was performed on an Agilent ZORBAX Eclipse XDB-C(18) column (150... |
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Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats.
Biomed. Chromatogr. 26(4) , 518-23, (2012) Leonurine (SCM-198), an alkaloid from Herba Leonuri, has been suggested as a novel cardiovascular agent by pharmacology studies in preclinical stage. In present study, we report a simple, rapid and sensitive high-performance liquid chromatography-tandem mass ... |
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Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells
Neurochem. Int. 58(8) , 851-60, (2011) Research highlights ► SCM198 (Leonurine) possessed neuroprotective potential both in vivo and in vitro. ► SCM198 exerted neuroprotective effect by inhibiting oxidative stress and apoptosis. ► We can develop therapeutic strategy for neurodegenerative diseases ... |
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Effects of leonurine hydrochloride on medically induced incomplete abortion in early pregnancy rats
Eur. J. Obstet. Gynecol. Reprod. Biol. 159(2) , 375-80, (2011) Objectives To determine the effect of leonurine hydrochloride (LH) on abnormal bleeding induced by medical abortion. |
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Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice.
Biosci. Rep. 32(2) , 185-95, (2012) There are reports of early evidence that suggest the involvement of chronic low-grade inflammation in the pathogenesis of Type 2 diabetes. Thus, substances that have effects in reducing inflammation could be potential drugs for Type 2 diabetes. Leonurine (4-g... |
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Effect of leonurine hydrochloride on endothelin and the endothelin receptor-mediated signal pathway in medically-induced incomplete abortion in rats.
Eur. J. Obstet. Gynecol. Reprod. Biol. 169(2) , 299-303, (2013) Endothelin (ET) is involved in uterine contractions. Our previous study showed that leonurine hydrochloride (LH) inhibits abnormal bleeding caused by incomplete abortion through an increase in uterine contractions in rats. The present study was conducted to s... |
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Effects of Leonurine on L-type calcium channel in rat ventricular myocytes.
Biol. Pharm. Bull. 35(8) , 1249-56, (2012) Leonurine (Leo) is a special alkaloid principle of Herba leonuri that has recently been suggested to improve cardiovascular functions. To date, there is no direct ionic evidence of Leo on regulating calcium channels in the heart. In the present study, we exam... |
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Leonurine: a new comer in the natural compounds affecting atherosclerosis.
Atherosclerosis 224(1) , 37-8, (2012)
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Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function.
Stroke 41(11) , 2661-8, (2010) Oxidative stress is known to be involved in ischemic stroke. Intense interest is drawn to the therapeutic potential of Chinese herbs on ischemic stroke because many of them contain antioxidant properties. Leonurine, 1 of the active compounds from purified Her... |