Kavain
Kavain structure
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Common Name | Kavain | ||
|---|---|---|---|---|
| CAS Number | 3155-48-4 | Molecular Weight | 230.259 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 432.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H14O3 | Melting Point | 142-148ºC | |
| MSDS | Chinese USA | Flash Point | 184.6±23.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Fatal kavalactone intoxication by suicidal intravenous injection.
Forensic Sci. Int. 249 , e7-11, (2015) Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were se... |
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Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
Phytomedicine 13(3) , 192-5, (2006) In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the mechanism of its hepatotoxicity, for example interactions ... |
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Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
Phytother Res. 25(3) , 417-23, (2011) While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, methysticin and yangonin on human hepatocytes (HepG2) and th... |
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Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
J. Clin. Pharm. Ther. 32(3) , 233-9, (2007) To examine the bioavailability of kavalactones in vitro and the possible differences in their bioavailability because of variations in either chemical structure or the method of extraction used.Caco-2 cell monolayers were used to determine the potential bioav... |
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Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.
Phytochem. Anal. 16(3) , 217-21, (2005) Three kava lactone constituents of Piper methysticum, namely, kawain, methysticin and desmethoxyyangonin, have been separated and identified by reversed-phase HPLC using superheated deuterium oxide as the mobile phase and on-line 1H-NMR detection. The method ... |
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Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
J. AOAC Int. 88(1) , 16-25, (2005) Kava (Piper methysticum) dietary products have been sold worldwide for treatment of nervous anxiety, tension, and restlessness. Recent reports showed potential association of kava usage and liver injuries. This study was conducted to develop simple and reliab... |
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Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
Int. J. Toxicol. 28(6 Suppl) , 175S-88S, (2009) Piper methysticum leaf/root/stem extract is the cosmetic ingredient name for a material derived from the leaves, roots, and stems of the Piper methysticum G. Forster plant, commonly known as kava kava. This and other kava-derived ingredients are used as skin-... |
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Enantioseparation of kavain on Chiralpak IA under normal-phase, polar organic and reversed-phase conditions.
J. Sep. Sci. 31(12) , 2206-10, (2008) First baseline HPLC enantioseparation of kavain is described. Complete enantiodiscrimination was achieved on the immobilised-type Chiralpak IA chiral stationary phase (CSP) using pure methanol and simple methanol-water and ethanol-water mixtures as eluents. A... |
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Kinetics of kavain and its metabolites after oral application.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 789(1) , 115-30, (2003) Kavain metabolism in humans was the target of this current investigation. In the present study a high-performance liquid chromatographic (HPLC-DAD) assay method for the simultaneous determination of kavain and its main metabolites (p-hydroxykavain, p-hydroxy-... |
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Testing for kavain in human hair using gas chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 798(2) , 351-4, (2003) A sensitive, specific and reproducible method for the quantitative determination of kavain in human hair has been developed. The sample preparation involved a decontamination step of the hair with methylene chloride. The hair sample (about 50 mg) was incubate... |