- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Kavain
- Price: ￥1768.0/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Kavain
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Kavain
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
3155-48-4
3155-48-4 structure
- Name: Kavain
- Chemical Name: Kavain
- CAS Number: 3155-48-4
- Molecular Formula: C14H14O3
- Molecular Weight: 230.259
- Catalog: Biochemical Plant extracts
- Create Date: 2018-05-26 08:00:00
- Modify Date: 2024-01-08 12:50:37
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Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic and sedative properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor[1].
| Name | Kavain |
|---|---|
| Synonyms |
DL-Kawain
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(E)-2-phenylethenyl]- 4-Methoxy-6-[(E)-2-phenylvinyl]-5,6-dihydro-2H-pyran-2-one trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,DL-Kawain KAVAIN,DL UNII:5L1NI60TGB Kawain,DL Kawain Kavain 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, (E)-(±)- MFCD00270446 Kawain, DL- 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl- Kavain, dl- DL-KAVAIN |
| Description | Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic and sedative properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor[1]. |
|---|---|
| In Vitro | Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L, α1βxγ2L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site. The β3N265M point mutation which has been previously shown to profoundly decrease anaesthetic sensitivity, also diminishes Kavain-mediated potentiation[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 432.6±45.0 °C at 760 mmHg |
| Melting Point | 142-148ºC |
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.259 |
| Flash Point | 184.6±23.3 °C |
| Exact Mass | 230.094299 |
| PSA | 35.53000 |
| LogP | 1.69 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.565 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |