Journal of Separation Science 2008-07-01

Enantioseparation of kavain on Chiralpak IA under normal-phase, polar organic and reversed-phase conditions.

Roberto Cirilli, Rosella Ferretti, Bruno Gallinella, Anna Rita Bilia, Franco Francesco Vincieri, Francesco La Torre

Index: J. Sep. Sci. 31(12) , 2206-10, (2008)

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Abstract

First baseline HPLC enantioseparation of kavain is described. Complete enantiodiscrimination was achieved on the immobilised-type Chiralpak IA chiral stationary phase (CSP) using pure methanol and simple methanol-water and ethanol-water mixtures as eluents. A water-dependent enantioselectivity was clearly demonstrated. Performance of the Chiralpak IA CSP in polar organic and RP conditions was compared with that of five coated polysaccharide-derived CSPs used in normal-phase mode.