6,7-Dihydroxycoumarin
6,7-Dihydroxycoumarin structure
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Common Name | 6,7-Dihydroxycoumarin | ||
|---|---|---|---|---|
| CAS Number | 305-01-1 | Molecular Weight | 178.141 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 469.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C9H6O4 | Melting Point | 271-273 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 201.5±22.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds.
Anal. Chim. Acta 882 , 49-57, (2015) Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds have low proton affinity and are poorly ionized by MALDI. ... |
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The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor.
J. Insect Physiol. 57(4) , 501-7, (2011) Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosanoids act in invertebrate biology. Prostaglandins (PGs) inf... |
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Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells.
Neurochem. Int. 90 , 204-14, (2015) Zinc oxide nanoparticles (ZnO NPs) are known to induce oxidative stress and modulate an inflammatory process in various cell types. Although the cytotoxic effects of ZnO NPs in various cell types have been evaluated, few neurotoxic surveys on ZnO NPs as well ... |
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Expanding the ChemGPS chemical space with natural products.
J. Nat. Prod. 68 , 985-91, (2005) Recently various attempts have been made to increase the efficacy and precision of chemical libraries used in high-throughput screening (HTS) drug discovery approaches. One such approach is ChemGPS, which provides a defined chemical space for prescreening eva... |
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Viola mandshurica ethanolic extract prevents high-fat-diet-induced obesity in mice by activating AMP-activated protein kinase.
Environ. Toxicol. Pharmacol. 38(1) , 41-50, (2014) Viola mandshurica W. Becker has been used as an expectorant, diuretic, and anti-inflammatory agent. We evaluated the effects of V. mandshurica ethanol extract (VME) on high-fat-diet (HFD)-induced obesity in mice. HPLC analysis showed that the VME contained 11... |
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Ectopic expression of a stress-inducible glycosyltransferase from saffron enhances salt and oxidative stress tolerance in Arabidopsis while alters anchor root formation.
Plant Sci. 234 , 60-73, (2015) Glycosyltransferases play diverse roles in cellular metabolism by modifying the activities of regulatory metabolites. Three stress-regulated UDP-glucosyltransferase-encoding genes have been isolated from the stigmas of saffron, UGT85U1, UGT85U2 and UGT85V1, w... |
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alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.
J. Nat. Prod. 71 , 910-3, (2008) Two new triterpenoids, 18alpha,19beta-20(30)-taraxasten-3beta,21alpha-diol (cichoridiol) (1) and 17-epi-methyl-6-hydroxyangolensate (intybusoloid) (2), were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, lupe... |
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Esculetin induces apoptosis in human colon cancer cells by inducing endoplasmic reticulum stress.
Cell Biochem. Funct. 33 , 487-94, (2015) Colorectal cancer has become more common in many regions of the world. Recently, we showed that esculetin, a natural coumarin, induces apoptosis in HT-29 colon cancer cells via the reactive oxygen species-mediated mitochondrial pathway. The present study exam... |
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Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers.
Planta Med. 79(2) , 131-6, (2013) Percutaneous transdermal absorption of esculetin (6,7-dihydroxycoumarin), an oxidative damage inhibitor, was evaluated by means of in vitro permeation studies in which vertical Franz-type diffusion cells and pig ear skin were employed. To determine the absorp... |
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Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.
Bioorg. Med. Chem. 16 , 2665-75, (2008) In the present study, we sought to establish the effect of diverse structural-related hydroxycoumarins on the proliferation, cytotoxicity, and induction of apoptosis in promonocytic leukemic cells (U-937). The dihydroxylated coumarins, 7,8-dihydroxy-coumarin ... |