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305-01-1

305-01-1 structure
305-01-1 structure
  • Name: 6,7-Dihydroxycoumarin
  • Chemical Name: esculetin
  • CAS Number: 305-01-1
  • Molecular Formula: C9H6O4
  • Molecular Weight: 178.141
  • Catalog: API Respiratory medication Asthma
  • Create Date: 2018-07-08 19:23:40
  • Modify Date: 2025-08-20 16:54:40
  • Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].
Name esculetin
Synonyms Aesculetin
Cryptotanshinone
ESCULETOL
CICHERINGENIN
Cichorigenin
Asculetine
Esculatin
6,7-Dihydroxycoumarin
Esculin aglycon
6,7-Dihydroxy-2H-chromen-2-one
esculetin
2H-1-Benzopyran-2-one, 6,7-dihydroxy-
6,7-dihydroxy-2H-1-benzopyran-2-one
Coumarin, 6,7-dihydroxy-
MFCD00006874
EINECS 206-161-5
Description Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].
Related Catalog
Target

PI3K

Akt

References

[1]. Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21.
Density 1.6±0.1 g/cm3
Boiling Point 469.7±45.0 °C at 760 mmHg
Melting Point 271-273 °C(lit.)
Molecular Formula C9H6O4
Molecular Weight 178.141
Flash Point 201.5±22.2 °C
Exact Mass 178.026611
PSA 70.67000
LogP 0.98
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.689
Storage condition 2-8°C
Water Solubility slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN6382500
CHEMICAL NAME :
Coumarin, 6,7-dihydroxy-
CAS REGISTRY NUMBER :
305-01-1
BEILSTEIN REFERENCE NO. :
0152788
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H6-O4
MOLECULAR WEIGHT :
178.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,714,1968
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GN6382500
Packaging Group I; II; III
HS Code 2932209090
HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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