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120-08-1

120-08-1 structure
120-08-1 structure
Name 6,7-Dimethoxycoumarin
Synonyms MFCD00006871
6,7-Dimethoxy-chromen-2-one
Scoparone
EINECS 204-369-0
Dimethylesculetin
6,7-dimethoxychromen-2-one
6,7-Dimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7-dimethoxy-
Description Scoparone is isolated from Artemisia capillaris, has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].
Related Catalog
In Vitro Scoparone (0-0.4 nM; 24-48 hours) produces the most inhibition on PSC proliferation at 0.4 nM[1].
In Vivo Scoparone (oral administration; 30 mg/kg, 60 mg/kg; 4 weeks) greatly ameliorates the pancreatic weight loss induced by DBTC in pancreatitis rats[1]. Animal Model: Chronic Pancreatitis (CP) Rat Models[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Oral administration; 30 mg/kg, 60 mg/kg; 4 weeks Result: Protected against pancreatic damage
References

[1]. Xu M, et al. Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats. Cell Physiol Biochem. 2016;40(1-2):277-286. Epub 2016 Nov 18.
Density 1.2±0.1 g/cm3
Boiling Point 369.2±42.0 °C at 760 mmHg
Melting Point 145°C
Molecular Formula C11H10O4
Molecular Weight 206.195
Flash Point 166.8±27.9 °C
Exact Mass 206.057907
PSA 48.67000
LogP 1.60
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.557

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN6550000
CHEMICAL NAME :
Coumarin, 6,7-dimethoxy-
CAS REGISTRY NUMBER :
120-08-1
BEILSTEIN REFERENCE NO. :
0169572
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H10-O4
MOLECULAR WEIGHT :
206.21
WISWESSER LINE NOTATION :
T66 BOVJ HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
292 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,550,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 60,763,1972 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1180 mg/kg
SEX/DURATION :
male 8 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - delayed effects
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 17,740,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
725 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 17,740,1979
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H319
Precautionary Statements P301 + P310-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R23/24/25
Safety Phrases S27/28-S36/37/39-S45-S26
RIDADR 2811
RTECS GN6550000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2932209090
HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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