Ditolylguanidine
Ditolylguanidine structure
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Common Name | Ditolylguanidine | ||
|---|---|---|---|---|
| CAS Number | 97-39-2 | Molecular Weight | 239.32 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 396.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H17N3 | Melting Point | 176-178 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 193.3±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination.
J. Neurosci. Res. 93(2) , 285-95, (2014) The γ-aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To investigate GABA and its B receptor in PNS development and dege... |
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Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice.
Neurobiol. Aging 36 , 1820-33, (2015) Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed. Here, we crossed both apoD-null mice and Thy-1 hum... |
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Monodisperse silica nanoparticles coated with gold nanoparticles as a sorbent for the extraction of phenol and dihydroxybenzenes from water samples based on dispersive micro-solid-phase extraction: Response surface methodology.
J. Sep. Sci. 38 , 2804-12, (2015) A selective and sensitive method was developed based on dispersive micro-solid-phase extraction for the extraction of hydroquinone, resorcinol, pyrocatechol and phenol from water samples prior to high-performance liquid chromatography with UV detection. SiO2 ... |
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Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22.
PLoS Genet. 11 , e1005253, (2015) Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest. The transitions from anagen (growth), to catagen (regression), to telogen (rest) involve a physiological involution of the HF. This process is likely coordinated ... |
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Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter.
Bioorg. Med. Chem. 23 , 4699-709, (2015) Nine fluorine-containing vesicular acetylcholine transporter (VAChT) inhibitors were synthesized and screened as potential PET tracers for imaging the VAChT. Compound 18a was one of the most promising carbonyl-containing benzovesamicol analogs; the minus enan... |
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Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase.
J. Virol. 89(6) , 3163-75, (2015) Dolutegravir (DTG) is the latest antiretroviral (ARV) approved for the treatment of human immunodeficiency virus (HIV) infection. The G118R substitution, previously identified with MK-2048 and raltegravir, may represent the initial substitution in a dolutegra... |
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The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir.
Antimicrob. Agents Chemother. 59(1) , 310-6, (2014) Clinical studies have shown that integrase strand transfer inhibitors (INSTIs) can be used effectively against HIV-1 infection. To date, no resistance substitution has been found in INSTI-naive patients treated with the new integrase inhibitor dolutegravir (D... |
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The sigma agonist 1,3-di-o-tolyl-guanidine reduces the morphological and behavioral changes induced by neonatal ventral hippocampus lesion in rats.
Synapse 69(4) , 213-25, (2015) Sigma (σ) receptors have generated a great deal of interest due to their possible role in psychosis, neuroprotection, and various other behaviors including addictive processes. Sigma receptors have been located in brain areas involved in motor functions, incl... |
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
PLoS ONE 9(11) , e111899, (2014) Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is re... |
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Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
J. Pharmacol. Exp. Ther. 350(2) , 290-300, (2014) Sigma-1 receptor (σ1R), an endoplasmic reticulum-chaperone protein, can modulate painful response after peripheral nerve injury. We have demonstrated that voltage-gated calcium current is inhibited in axotomized sensory neurons. We examined whether σ1R contri... |