Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Di-o-tolylguanidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Di-o-tolylguanidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Ditolylguanidine
Price: ￥Inquiry/25kg
Purity: 99.0%
Stocking Period: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

97-39-2

97-39-2 structure

Name: Ditolylguanidine
Chemical Name: 1,3-Di-o-tolylguanidine
CAS Number: 97-39-2
Molecular Formula: C₁₅H₁₇N₃
Molecular Weight: 239.32
Catalog: Chemical reagent Organic reagent Barium salt
Create Date: 2018-09-23 05:45:57
Modify Date: 2025-08-25 16:26:12
Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) is an agonist of sigma receptor (σ1/σ2 receptor)[1].

Name	1,3-Di-o-tolylguanidine
Synonyms	MFCD00008513 1,3-Bis(o-tolyl)guanidine Guanidine, N,N''-bis(2-methylphenyl)- N,N'-Di-o-tolylguanidine EINECS 202-577-6 N,N'-Bis(2-methylphenyl)guanidine Di-o-tolylguanidine Guanidine, 1,3-di-o-tolyl- 1R BMYUM&MR B1 1,2-Bis(2-methylphenyl)guanidine

Description	Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) is an agonist of sigma receptor (σ1/σ2 receptor)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Sigma receptor[1]
References	[1]. Skuza G, et al. Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. Pol J Pharmacol. 2003 Nov-Dec;55(6):1149-52.

Density	1.1±0.1 g/cm3
Boiling Point	396.1±45.0 °C at 760 mmHg
Melting Point	176-178 °C(lit.)
Molecular Formula	C₁₅H₁₇N₃
Molecular Weight	239.32
Flash Point	193.3±28.7 °C
Exact Mass	239.142242
PSA	47.91000
LogP	3.77
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.585
Storage condition	Store at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF1400000

CHEMICAL NAME :: Guanidine, 1,3-di-o-tolyl-

CAS REGISTRY NUMBER :: 97-39-2

BEILSTEIN REFERENCE NO. :: 2653884

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H17-N3

MOLECULAR WEIGHT :: 239.35

WISWESSER LINE NOTATION :: 1R BMYUM&MR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81800 No. of Facilities: 157 (estimated) No. of Industries: 5 No. of Occupations: 23 No. of Employees: 3729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81800 No. of Facilities: 492 (estimated) No. of Industries: 7 No. of Occupations: 18 No. of Employees: 22254 (estimated) No. of Female Employees: 4255 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	UN 2811
WGK Germany	3
RTECS	MF1400000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2925290090

Precursor 10
615-37-2 506-93-4 124-46-9 646-34-4
95-46-5 22695-18-7 95-53-4 506-77-4
137-97-3 7664-41-7
DownStream 3
3467-29-6 4132-53-0 7783-06-4

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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