Ditolylguanidine

Modify Date: 2024-01-03 12:22:00

Ditolylguanidine structure	Common Name	Ditolylguanidine
	CAS Number	97-39-2	Molecular Weight	239.32
	Density	1.1±0.1 g/cm3	Boiling Point	396.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₇N₃	Melting Point	176-178 °C(lit.)
	MSDS	Chinese USA	Flash Point	193.3±28.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Ditolylguanidine

Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) is an agonist of sigma receptor (σ1/σ2 receptor)[1].

Name	1,3-Di-o-tolylguanidine
Synonym	More Synonyms

Description	Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) is an agonist of sigma receptor (σ1/σ2 receptor)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Sigma receptor[1]
References	[1]. Skuza G, et al. Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. Pol J Pharmacol. 2003 Nov-Dec;55(6):1149-52.

Density	1.1±0.1 g/cm3
Boiling Point	396.1±45.0 °C at 760 mmHg
Melting Point	176-178 °C(lit.)
Molecular Formula	C₁₅H₁₇N₃
Molecular Weight	239.32
Flash Point	193.3±28.7 °C
Exact Mass	239.142242
PSA	47.91000
LogP	3.77
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.585
Storage condition	Store at RT

Ditolylguanidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF1400000

CHEMICAL NAME :: Guanidine, 1,3-di-o-tolyl-

CAS REGISTRY NUMBER :: 97-39-2

BEILSTEIN REFERENCE NO. :: 2653884

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H17-N3

MOLECULAR WEIGHT :: 239.35

WISWESSER LINE NOTATION :: 1R BMYUM&MR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81800 No. of Facilities: 157 (estimated) No. of Industries: 5 No. of Occupations: 23 No. of Employees: 3729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81800 No. of Facilities: 492 (estimated) No. of Industries: 7 No. of Occupations: 18 No. of Employees: 22254 (estimated) No. of Female Employees: 4255 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	UN 2811
WGK Germany	3
RTECS	MF1400000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2925290090

Precursor 10
CAS#:615-37-2 4-Iodotoluene CAS#:506-93-4 Guanidine nitrate CAS#:124-46-9 carbonic acid; ... CAS#:646-34-4 guanidine
CAS#:95-46-5 2-Bromotoluene CAS#:22695-18-7 N,N-di-o-tolylt... CAS#:95-53-4 o-Toluidine CAS#:506-77-4 Cyanogen chloride
CAS#:137-97-3 1,3-di(o-tolyl)... CAS#:7664-41-7 Ammonia
DownStream 3
CAS#:3467-29-6 3H-1,2-Dithiole... CAS#:4132-53-0 4-(4-(tert-buty... CAS#:7783-06-4 hydrogen sulfide

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination.

J. Neurosci. Res. 93(2) , 285-95, (2014)

The γ-aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To inve...

Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice.

Neurobiol. Aging 36 , 1820-33, (2015)

Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been ad...

Monodisperse silica nanoparticles coated with gold nanoparticles as a sorbent for the extraction of phenol and dihydroxybenzenes from water samples based on dispersive micro-solid-phase extraction: Response surface methodology.

J. Sep. Sci. 38 , 2804-12, (2015)

A selective and sensitive method was developed based on dispersive micro-solid-phase extraction for the extraction of hydroquinone, resorcinol, pyrocatechol and phenol from water samples prior to high...

MFCD00008513

1,3-Bis(o-tolyl)guanidine

Guanidine, N,N''-bis(2-methylphenyl)-

N,N'-Di-o-tolylguanidine

EINECS 202-577-6

N,N'-Bis(2-methylphenyl)guanidine

Di-o-tolylguanidine

Guanidine, 1,3-di-o-tolyl-

1R BMYUM&MR B1

1,2-Bis(2-methylphenyl)guanidine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Di-o-tolylguanidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Di-o-tolylguanidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Ditolylguanidine suppliers

Price: ￥390/100g

Reference only. check more Ditolylguanidine price

Ditolylguanidine

Use of Ditolylguanidine

Names