10-Oxo Morphine
10-Oxo Morphine structure
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Common Name | 10-Oxo Morphine | ||
|---|---|---|---|---|
| CAS Number | 68254-48-8 | Molecular Weight | 299.32100 | |
| Density | 1.53g/cm3 | Boiling Point | 557ºC at 760 mmHg | |
| Molecular Formula | C17H17NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 290.6ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.
J. Pharm. Sci. 92(3) , 485-93, (2003) Stability testing of morphine sulfate formulated with nonpareil sugar seeds (consisting of sucrose and starch) and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine. 5-(Hydroxymethy... |
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Synthesis and determination of 10-oxomorphine, a decomposition product of morphine.
Pharmazie 39(10) , 687-8, (1984) 10-Oxomorphine, a decomposition product of morphine, was synthesized from 6-O-acetylcodeine, which was oxidized with chromic acid to 6-O-acetyl-10-hydroxycodeine. This substance was then oxidized with manganese dioxide to 6-O-acetyl-10-oxocodeine, which on hy... |
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