Z-Gly-Phe-OH
Z-Gly-Phe-OH structure
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Common Name | Z-Gly-Phe-OH | ||
|---|---|---|---|---|
| CAS Number | 1170-76-9 | Molecular Weight | 356.37300 | |
| Density | 1.278 g/cm3 | Boiling Point | 646ºC at 760 mmHg | |
| Molecular Formula | C19H20N2O5 | Melting Point | 125-126 °C | |
| MSDS | USA | Flash Point | 344.5ºC | |
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Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase.
Biosci. Rep. 6(7) , 647-53, (1986) Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane... |
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Synthesis and conformational study of a cyclic hexapeptide analogue of somatostatin: cyclo(Phe-D-Trp-Lys-Thr-o-AMPA).
J. Pept. Protein Res. 29 , 464, (1987) The active sequence Phe7-D-Trp8-Lys9-Thr10 of somatostatin has been cyclized through o-(aminomethyl)phenylacetic acid, a spacer molecule, designed to mimic a Gly-Gly dipeptide containing a cis-constrained peptide bond. The resulting analogue shows no GH-inhib... |
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Insulin receptor autophosphorylation and signaling is altered by modulation of membrane physical properties.
Biochemistry 34(6) , 1815-24, (1995) Many membrane functions are modulated by the bulk biophysical properties of the membrane. Various compounds which alter membrane physical properties were investigated for their ability to modulate insulin receptor autophosphorylation and signaling. Compounds ... |
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Determination of pancreatic carboxypeptidase A in human blood serum.
Clin. Chim. Acta 135(1) , 65-71, (1983) A method has been designed for the assay of pancreatic carboxypeptidase A in blood serum. It uses Z-Gly-Phe as the substrate and fluorimetric determination of the released phenylalanine in an amino acid analyser, which yields a measure of free carboxypeptidas... |
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Evidence suggesting a role for sperm metalloendoprotease activity in penetration of zona-free hamster eggs by human sperm.
J. Exp. Zool. 248(2) , 213-21, (1988) It has been reported that metalloendoprotease (MEP) activity is involved in somatic cell membrane fusion events and in the sea urchin sperm acrosome reaction (AR). MEP activity also has been demonstrated in human and other mammalian sperm. The present study w... |
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Lysosomotropic agents. 4. Carbobenzoxyglycylphenylalanyl, a new protease-sensitive masking group for introduction into cells.
J. Med. Chem. 25(5) , 539-44, (1982) Bioactive primary and secondary amines, when acylated with the Z-Gly-Phe group, are transported into pinocytic cells, such as macrophages, P-815 mastocytoma, SV-40 3T3, and leukemia 1210, much faster than the parent compounds. Amines such as lysosomotropic de... |
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Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol.
J. Biol. Chem. 267(6) , 3932-9, (1992) HepG2 cells were employed as model system to investigate potential relationships between early protein processing and Ca2+ storage by the endoplasmic reticulum. Ca2+ was required for glycoprotein processing and export by intact cells. The processing and expor... |
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A thioamide substrate of carboxypeptidase A.
Biochemistry 21(7) , 1608-11, (1982) Carbobenzoxythioglycyl-L-phenylalanine [CbzNHCH2C(==S)Phe, Z-Glys-Phe] was synthesized as thioamide analogue of Z-Gly-Phe, a known substrate of carboxypeptidase A (CPA). By use of a ninhydrin-based assay and Z-Gly-Gly-Phe as the substrate, Z-Glys-Phe was show... |
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Effects of three proposed inhibitors of adipocyte glucose transport on the reconstituted transporter.
Biochim. Biophys. Acta 979(3) , 331-40, (1989) Three compounds which inhibit glucose transport in rat adipocytes have been proposed to act directly on the glucose transporter protein. We tested these proposals by examining the effects of the compounds on the stereospecific glucose uptake catalyzed by adip... |
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Transition-state characterization: a new approach combining inhibitor analogues and variation in enzyme structure.
Biochemistry 31(4) , 959-63, (1992) A new strategy of potentially broad application for probing transition-state (TS) analogy in enzymatic systems is described in this paper. The degree to which a series of phosphonate inhibitors act as TS analogues of rat carboxypeptidase A1 has been determine... |