alpha-Phenyl-2-piperidineacetic acid hydrochloride
alpha-Phenyl-2-piperidineacetic acid hydrochloride structure
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Common Name | alpha-Phenyl-2-piperidineacetic acid hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 19395-40-5 | Molecular Weight | 255.74100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H18ClNO2 | Melting Point | 248℃ | |
| MSDS | N/A | Flash Point | 9℃ | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Potential trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: wastewater analysis of amphetamine and ritalinic acid.
Sci. Total Environ. 450-451 , 242-9, (2013) Attention Deficit Hyperactivity Disorder (ADHD) medication use is on the rise in the United States. The most widely used ADHD medications are the amphetamine-type compounds Adderall (mixed amphetamine salts) and Ritalin (methylphenidate). According to survey ... |
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A safer methylation procedure with boron trifluoride-methanol reagent for gas chromatographic analysis of ritalinic acid in urine.
J. Pharm. Biomed. Anal. 10 , 187, (1992) Ritalinic acid (RITA), the major metabolite of methylphenidate (Ritaline) is extracted with a solid-phase C8 column. Following elution, methylation of the carboxylic group is performed with boron trifluoride-methanol as a reagent. The methyl ester of RITA whi... |
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Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.
J. Clin. Psychopharmacol. 19(4) , 362-6, (1999) Methylphenidate is the most commonly prescribed psychostimulant in clinical use today. Known methylphenidate metabolites include ritalinic acid, corresponding lactams, and p-hydroxymethylphenidate. Recent in vitro work using rat liver preparations has indicat... |
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Determination of methylphenidate and ritalinic acid in blood, plasma and oral fluid from adolescents and adults using protein precipitation and liquid chromatography tandem mass spectrometry—A method applied on clinical and forensic investigations
J. Pharm. Biomed. Anal. 55(5) , 1050-9, (2011) A validated, accurate and sensitive LC–MS/MS method for determination of racemic methylphenidate and its metabolite ritalinic acid has been developed. The analytes were quantified by tandem mass spectrometry operating in positive electrospray ionization mode ... |
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Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.
Rapid Commun. Mass Spectrom. 14(8) , 619-23, (2000) Methylphenidate (MP, Ritalin) is a psychotropic drug widely prescribed to children for treating the symptoms of attention deficit disorder with and without hyperactivity. Because little information exists about the effects of chronic MP administration on cogn... |
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Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system.
Chemosphere 81(11) , 1416-22, (2010) To investigate the occurrence and fate of ritalinic acid - the main human metabolite of the psychostimulant drug methylphenidate - in the aquatic environment, a HPLC-electrospray-MS/MS method for the quantification of ritalinic acid in wastewater, surface wat... |
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Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.
J. Clin. Psychopharmacol. 20(3) , 347-9, (2000) Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had n... |
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Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.
J. Pharm. Sci. 81(8) , 747-9, (1992) Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate (MPH) and its major metabolite, dl-ritalinic acid (RA), were examined in a cohort of healthy subjects. On two occasions, separated by one week, each subject received MPH.HCl either intraveno... |
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Enantioselective analysis of ritalinic acids in biological samples by using a protein-based chiral stationary phase.
Pharm. Res. 20(11) , 1881-4, (2003) This study was to develop and validate a new chiral HPLC-UV method for the quantitative analysis of enantiomeric ritalinic acid (RA) in human plasma.An alpha1-acid glycoprotein column was used with the mobile phase containing 0.4% acetic acid and 0.1% dimethy... |
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HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection.
Anal. Bioanal. Chem 400(2) , 387-93, (2011) An HPLC-peroxyoxalate chemiluminescence (PO-CL) method for simultaneous determination of methylphenidate (MPH) and ritalinic acid (RA) was developed. The method was used to monitor MPH and RA after administration of MPH to rats. Deproteinized plasma spiked wi... |