Journal of Clinical Psychopharmacology 2000-06-01

Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.

C L DeVane, J S Markowitz, S W Carson, D W Boulton, H S Gill, Z Nahas, S C Risch

Index: J. Clin. Psychopharmacol. 20(3) , 347-9, (2000)

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Abstract

Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers. These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration.