Ritalinic acid
Ritalinic acid structure
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Common Name | Ritalinic acid | ||
|---|---|---|---|---|
| CAS Number | 19395-41-6 | Molecular Weight | 219.280 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 367.7±17.0 °C at 760 mmHg | |
| Molecular Formula | C13H17NO2 | Melting Point | 236-238ºC | |
| MSDS | Chinese USA | Flash Point | 176.2±20.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Determination of amphetamine and methylphenidate in exhaled breath of patients undergoing attention-deficit/hyperactivity disorder treatment.
Ther. Drug Monit. 36(4) , 528-34, (2014) It has been discovered recently that exogenous substances are detectable in exhaled breath after intake. Exhaled breath therefore constitutes a new possible matrix in clinical pharmacology and toxicology. The present work was aimed at exploring this possibili... |
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Pharmacological Cognitive Enhancement in Healthy Individuals: A Compensation for Cognitive Deficits or a Question of Personality?
PLoS ONE 10 , e0129805, (2015) The ongoing bioethical debate on pharmacological cognitive enhancement (PCE) in healthy individuals is often legitimated by the assumption that PCE will widely spread and become desirable for the general public in the near future. This assumption was question... |
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Potential trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: wastewater analysis of amphetamine and ritalinic acid.
Sci. Total Environ. 450-451 , 242-9, (2013) Attention Deficit Hyperactivity Disorder (ADHD) medication use is on the rise in the United States. The most widely used ADHD medications are the amphetamine-type compounds Adderall (mixed amphetamine salts) and Ritalin (methylphenidate). According to survey ... |
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A safer methylation procedure with boron trifluoride-methanol reagent for gas chromatographic analysis of ritalinic acid in urine.
J. Pharm. Biomed. Anal. 10 , 187, (1992) Ritalinic acid (RITA), the major metabolite of methylphenidate (Ritaline) is extracted with a solid-phase C8 column. Following elution, methylation of the carboxylic group is performed with boron trifluoride-methanol as a reagent. The methyl ester of RITA whi... |
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Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.
J. Clin. Psychopharmacol. 19(4) , 362-6, (1999) Methylphenidate is the most commonly prescribed psychostimulant in clinical use today. Known methylphenidate metabolites include ritalinic acid, corresponding lactams, and p-hydroxymethylphenidate. Recent in vitro work using rat liver preparations has indicat... |
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Determination of methylphenidate and ritalinic acid in blood, plasma and oral fluid from adolescents and adults using protein precipitation and liquid chromatography tandem mass spectrometry—A method applied on clinical and forensic investigations
J. Pharm. Biomed. Anal. 55(5) , 1050-9, (2011) A validated, accurate and sensitive LC–MS/MS method for determination of racemic methylphenidate and its metabolite ritalinic acid has been developed. The analytes were quantified by tandem mass spectrometry operating in positive electrospray ionization mode ... |
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Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.
Rapid Commun. Mass Spectrom. 14(8) , 619-23, (2000) Methylphenidate (MP, Ritalin) is a psychotropic drug widely prescribed to children for treating the symptoms of attention deficit disorder with and without hyperactivity. Because little information exists about the effects of chronic MP administration on cogn... |
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Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system.
Chemosphere 81(11) , 1416-22, (2010) To investigate the occurrence and fate of ritalinic acid - the main human metabolite of the psychostimulant drug methylphenidate - in the aquatic environment, a HPLC-electrospray-MS/MS method for the quantification of ritalinic acid in wastewater, surface wat... |
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Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.
J. Clin. Psychopharmacol. 20(3) , 347-9, (2000) Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had n... |
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Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.
J. Pharm. Sci. 81(8) , 747-9, (1992) Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate (MPH) and its major metabolite, dl-ritalinic acid (RA), were examined in a cohort of healthy subjects. On two occasions, separated by one week, each subject received MPH.HCl either intraveno... |