2-Methoxy-5-Bromopyridine

2-Methoxy-5-Bromopyridine Structure
2-Methoxy-5-Bromopyridine structure
Common Name 2-Methoxy-5-Bromopyridine
CAS Number 13472-85-0 Molecular Weight 188.02
Density 1.5±0.1 g/cm3 Boiling Point 197.0±20.0 °C at 760 mmHg
Molecular Formula C6H6BrNO Melting Point 80ºC (12 mmHg)
MSDS Chinese USA Flash Point 72.9±21.8 °C
Symbol GHS07
GHS07
Signal Word Warning

An efficient synthesis of an alphavbeta3 antagonist.

J. Org. Chem. 69 , 1959-1966, (2004)

A practical preparation of an alpha(v)beta(3) antagonist is reported. The antagonist consists of three key components, a tetrahydronaphthyridine moiety, a beta-alanine moiety, and a central imidazolidone moiety. The tetrahydronaphthyridine component was prepa...

Non-peptide alpha v beta 3 antagonists. Part 7: 3-Substituted tetrahydro-naphthyridine derivatives.

Bioorg. Med. Chem. Lett. 14 , 1049, (2004)

A series of 3-substituted tetrahydro-[1,8]naphthyridine containing alpha(v)beta(3) antagonists was prepared. A comparison of their in vitro IC(50) values to the electron properties of the 3-substituents revealed a good linear Hammett correlation (rho=-1.96, R...

Tetrahedron Asymmetry 14 , 3469, (2003)

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A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate.
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Org. Process Res. Dev. 11(5) , 899-902, (2007)

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Bioorg. Med. Chem. Lett. 18(14) , 4195-4198, (2008)

Negishi Cross-Coupling Reactions Catalyzed by an Aminophosphine-Based Nickel System: A Reliable and General Applicable Reaction Protocol for the High-Yielding Synthesis of Biaryls. Gerber R and Frech CM.

Chemistry 17(42) , 11893-11904, (2011)