2,2':6',2''-TERPYRIDINE
2,2':6',2''-TERPYRIDINE structure
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Common Name | 2,2':6',2''-TERPYRIDINE | ||
|---|---|---|---|---|
| CAS Number | 1148-79-4 | Molecular Weight | 233.268 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 402.3±35.0 °C at 760 mmHg | |
| Molecular Formula | C15H11N3 | Melting Point | 90-93 °C | |
| MSDS | Chinese USA | Flash Point | 182.5±18.9 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Thousands of chemical starting points for antimalarial lead identification.
Nature 465 , 305-10, (2010) Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with redu... |
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Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.
Bioorg. Med. Chem. Lett. 16 , 5982-7, (2006) Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated tha... |
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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008) The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-throughput cell-based screen (1,536-well format) based on p... |
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Rapid and sensitive amino-acid sequencing of cloning Thermus thermophilus HB8 ferredoxin by proteomics.
J. Proteome Res. 3(5) , 983-7, (2004) Recombinant holo Thermus thermophilus [7Fe-8S] ferredoxin was synthesized by cloning from Thermus thermophilus HB8 gene. A specific sequence (Pro-His-Val-Ile) at the N-terminus of the recombinant ferredoxin was determined by a rapid and highly sensitive mass ... |
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Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities.
Eur. J. Med. Chem. 43 , 675-82, (2008) For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared com... |
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Achieving large color changes in response to the presence of amino acids: a molecular sensing ensemble with selectivity for aspartate.
J. Am. Chem. Soc. 123(45) , 11296-7, (2001)
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Efficient new ribozyme mimics: direct mapping of molecular design principles from small molecules to macromolecular, biomimetic catalysts.
Nucleic Acids Res. 29(10) , 2199-204, (2001) Dramatic improvements in ribozyme mimics have been achieved by employing the principles of small molecule catalysis to the design of macromolecular, biomimetic reagents. Ribozyme mimics derived from the ligand 2,9-dimethylphenanthroline (neocuproine) show at ... |
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Modification of 2,2',2''-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines.
Pharmacol. Biochem. Behav. 48(3) , 665-70, (1994) The administration of 2,2',2''-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, wh... |
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Synthesis, structures, spectroscopic and electrochemical properties of dinitrosyl iron complexes with bipyridine, terpyridine, and 1,10-phenathroline.
Inorg. Chem. 48(20) , 9779-85, (2009) Three new dinitrosyl iron complexes LFe(NO)(2) (L = 2,2'-bipyridine (bipy) (1), 2,2',2''-terpyridine (terpy) (2) and 1,10-phenathroline (phen) (3)) were synthesized by the reaction of Fe(NO)(2)(CO)(2) with corresponding ligands in tetrahydrofuran. Complexes 1... |
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Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.
Bioorg. Med. Chem. Lett. 11(19) , 2659-62, (2001) For the development of new anticancer agents, 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicat... |